초록
Neurolymphomatosis (NL) is a rare disease characterized by lymphomatous invasion of the cranial or peripheral nerves by lymphoma. A high suspicion is important due to the various presenting symptoms mandating consideration of many differential diagnoses. We report a case of NL of the cranial nerves and plexus presenting as diplopia, facial palsy, and weakness of the upper and lower limbs in sequence.
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REFERENCES
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![]() | Fig. 1.Brain and spinal MRI showed thickening and enhancement on the left facial nerve (arrow) (A), and the left brachial plexus (arrow) (B). Initial PET-CT showed mild linear FDG uptake along the left brachial plexus (arrow) (C). Brain MRI revealed multifocal leptomeningeal enhancement of the systemic lymphoma or metastasis (D). FDG-PET revealed intense uptake in the brachial (arrows) (E) and lumbosacral (arrows) (F) plexus. MRI, magnetic resonance imaging; PET-CT, positron emission tomography–computed tomography; FDG, fluorodexoyglucose. |
![]() | Fig. 2.Biopsy of the C7 root showed infiltration by predominantly small lymphocytes (hematoxylin-eosin stain, original magnification ×200) (A), and diffuse CD20-positive cells (immunohistochemical stain, original magnification ×200) (B). |
Table 1.
Electrophysiological findings at the first symptoms of left upper limb weakness