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Ko, Jwa, Park, and Kang: Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 and anti-GD1b antibodies
Case Report

Ann Clin Neurophysiol 2017;19(1):54-57.

Published online: 5 January 2017

DOI: https://doi.org/10.14253/acn.2017.19.1.54

Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 and anti-GD1b antibodies

Keun Hyuk Ko, Seung-Joo Jwa, Sung Joo Park, Sa-Yoon Kang

Department of Neurology, Jeju National University School of Medicine, Jeju, Korea

Correspondence to Sa-Yoon Kang Department of Neurology, Jeju National University School of Medicine, 102 Jeju-daehak-ro, Jeju 62343, Korea Tel: +82-64-754-8175 Fax: +82-64-717-1630 E-mail: neurokang@jejunu.ac.kr

Received 21 April 201622 July 2016       Accepted 25 July 2016

Copyright © 2017 The Korean Society of Clinical Neurophysiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

초록

Distal acquired demyelinating symmetric (DADS) neuropathy is a variant form of chronic inflammatory demyelinating polyradiculoneuropathy. A 54-year-old man presented with gait disturbance owing to weakness in both legs. Nerve conduction studies showed demyelinating sensorimotor polyneuropathy, and laboratory studies demonstrated anti-GM1 and anti-GD1b IgG antibodies, but no anti-myelin associated glycoprotein activity. We suggest that an antiganglioside antibodies assay needs to be applied when DADS neuropathy is suspected in order to improve the classification of dysimmune neuropathies.

Keywords: Gangliosides, Antibodies, Demyelination, Neuropathy

REFERENCES

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Table 1.
Data obtained in the nerve conduction studies of the patient
Motor nerve conduction studies
Nerve Latency (ms) Amplitude (mV) CV (m/s) Latency (ms) Amplitude (mV) CV (m/s)
Median, Rt/Lt            
Wrist 7.97 (< 3.60) 10.07 (> 5)   5.63 8.33  
Elbow   9.34 28.83 (> 49.96)   7.41 30.16
Axilla   9.11 41.35 (> 55.96)   7.21 42.87
Ulnar, Rt/Lt            
Wrist 6.41 (< 2.51) 12.04 (> 5)   5.94 13.05  
Elbow   10.33 29.28 (> 50.61)   11.04 30.39
Axilla   9.30 34.38 (> 52.69)   9.15 41.26
Tibial, Rt/Lt            
Ankle 10.16 (< 5.11) 3.04 (> 5)   10.94 4.80  
Knee   2.3 33.82 (> 40.63)   3.56 27.32
Peroneal, Rt/Lt            
Ankle NR     NR    
Knee NR     NR    
    Sensory nerve conduction studies    
Nerve   Amplitude (μV)   CV (m/s) Amplitude (μV) CV (m/s)
Median, Rt/Lt            
Third digit   9.51 (> 10) 24.87 (> 41.26) 7.62 29.34
Wrist   23.65 35.71 (> 49.39) 13.11 35.54
Elbow   62.32 44.53 (> 53.90) 50.37 42.90
Ulnar, Rt/Lt            
Fifth digit   12.40 (> 10) 26.46 (> 39.26) 11.57 27.58
Wrist   24.35 34.32 (> 47.46) 21.50 35.16
Elbow   40.35 27.92 (> 48.18) 36.61 36.59
Sural, Rt/Lt            
Lateral malleolus, 14 cm   5.36 (> 6) 21.57 (> 34.68) 4.75 20.45
CV, conduction velocity; Lt, left; NR, no response; Rt, right; ( ), normal range.
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