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Table 1.
Adverse effect of Penicillin
Adverse effect
Frequency
Penicillin
Allergy
Anaphylaxis
0.004 ~ 0.04%
Penicillin
Skin rash
4%(8%)
Ampicillin
Serum sickness
rare
Penicillin G
G-I trouble
Diarrhea
25%
Ampicillin
Gastroenteritis
<1%
Ampicillin
Hematologic disorder
Hemolytic anemia
rare
Penicillin G
Neutropenia
rare
Penicillin G,
Oxacillin
Platelet function abnormality
3%
carbenicillin
Liver disorder
AST, ALT elevation
Uncommon
Oxacillin,
Nafcillin
Alkaline phosphatase elevation
Carbenicillin
Electrolyte disorder
Na overload
variable
Carbenicillin
Hypokalemia
variable
Carbenicillin
Hyperkalemia
rare
Penicillin G
Neurologic disorders
Convulsion
rare
Penicillin G
Sensory abnormality
unknown
Procaine penicillin
Renal disorder
Inerstitial nephritis
unknown
Methicillin
(Mandell GL et al., In Principles and Practice of Infectious Disease)