Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications

David Chun Ern Ng; L. Alexis Anand; Fu Lung Khiu; Kah Kee Tan

doi:10.14776/piv.2018.25.1.50

Journal List > Pediatr Infect Vaccine > v.25(1) > 1098704

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Ng, Anand, Khiu, and Tan: Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications

Case Report

Pediatr Infect Vaccine 2018;25(1):50-53.

Published online: 20 January 2018

DOI: https://doi.org/10.14776/piv.2018.25.1.50

Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications

David Chun Ern Ng, L. Alexis Anand, Fu Lung Khiu, Kah Kee Tan

Department of Pediatric, Tuanku Ja'afar Hospital, Seremban, Malaysia

책임저자: David Chun Ern Ng Department of Pediatric, Tuanku Ja'afar Hospital, Seremban, Malaysia Tel: +60-6-768-4000, Fax: +60-6-763-2900 E-mail: davidngce@gmail.com

Received 9 August 2017 Revised 8 November 2017 Accepted 1 December 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Staphylococcus aureus is a well-recognized human pathogen that causes a wide range of infections as a result of its extensive virulence factors. One of these factors is Panton-Valentine leukocidin (PVL), a potent pore-forming cytotoxin that has been linked to invasive S. aureus infections. PVL is one of the important virulence factors for S. aureus and has been largely recognized as one of the markers for community-acquired methicillin-resistant S. aureus. However, the presence of PVL in methicillin-susceptible S. aureus infections is not widely reported in the literature. Thrombotic sequelae of S. aureus infections associated with PVL expression are uncommon in children. We hereby report two children with thrombotic complications associated with PVL-producing methicillin-susceptible S. aureus. Both patients responded well to antibiotic and anticoagulant therapies, and survived without any long-term sequelae.

Keywords: Panton-Valentine leukocidin, Staphylococcus aureus, Child

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Fig. 1.

Filling defect seen within the enlarged right cavernous sinus (arrow) with proptosis of right globe for patient 1.

Fig. 2.

Ultrasound Doppler at transverse section over right common femoral vein (RCFV) and right popliteal vein (R POP V) showed an echogenic thrombus within with no Doppler signal for patient 2. Abbreviation: WC, with compression.

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