Analysis of Physical Properties for Various Compositions of Reusable LMG and LCV Micelle Gel

Jin Mook Kang; Dong Han Lee; Yu Ra Cho; Seon Bung Hwang; Young Hoon Ji; So Hyun Ahn; Re Na Lee; Sam Ju Cho; Insup Noh

doi:10.14316/pmp.2016.27.4.175

Journal List > Prog Med Phys > v.27(4) > 1098550

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Kang, Lee, Cho, Hwang, Ji, Ahn, Lee, Cho, and Noh: Analysis of Physical Properties for Various Compositions of Reusable LMG and LCV Micelle Gel

Original Article

Progress in Medical Physics 2016;27(4):175-179.

Published online: 17 December 2016

DOI: https://doi.org/10.14316/pmp.2016.27.4.175

Analysis of Physical Properties for Various Compositions of Reusable LMG and LCV Micelle Gel

Jin Mook Kang^∗,^§, Dong Han Lee^∗, Yu Ra Cho^∗, Seon Bung Hwang^∗, Young Hoon Ji^∗, So Hyun Ahn^†, Re Na Lee^‡, Sam Ju Cho^‡, Insup Noh^§,

^∗Korea Institute of Radiological and Medical Sciences, Seoul, Korea

^†Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea

^‡Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea

^§Department of Chemical and Biomolecular Engineering, Seoul National University, Seoul, Korea

Correspondence: Insup Noh (insup@seoultech.ac.kr) Tel: 82-2-970-6603, Fax: 82-2-977-8317

Received 10 November 201624 November 2016 Accepted 25 November 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study, we evaluated the reusable leuco malachite green (LMG) micelle gel properties dependent on various components of chemical concentration and compared with leuco crystal violet (LCV). The gels were delivered to 10, 20, 30, 40 and 50 Gy at 6 MV photon beam from linear accelerator and analyzed using spectrophotometry. We confirmed that the reusable LMG and LVC absorbance wavelength peak were made up at 630 nm and 600 nm respectively. The transparency of reusable LMG decreased with higher amount of trichloroacetic acid (TCAA) and lower reusable LMG dyes. 1 mM reusable LMG was the lowest transparency. The sensitivity was increased depending on lower trichloroacetic acid (TCAA) concentrations and the amount of suitable surfactant (Triton X-100), which was found to be 7 mM. However, we were not able to investigate sensitivity effects factor from reusable LMG dyes. The gel dosimeter containing 16 mM TCAA, 7 mM Triton X-100 gel dosimeter showed the highest sensitivity at 0.0021±0.0001 cm⁻¹. Gy⁻¹. The sensitivity of LCV was found to be higher than reusable LMG at 0.0037±0.0005 cm⁻¹. Gy⁻¹. The reusable LMG and LCV dose responses were shown to be R²=0.997, R²=0.999 respectively, as stable measurement results. Future research is necessary to improve dose sensitivity, dose rate dependency and gel fading with extensive chemical formulations.

Keywords: Reusable LMG, LCV micell gel, Sensitivity, Dose response

REFERENCES

1. Vandecasteel J, Ghysel S, Baete S H, et al. Radio- Physical properties of micelle leucidye 3D intergrating gel dosimeters Phys. Med. Biol. 56:627. 2011.

2. Maryanski MJ, Ibbott GS, Eastman P, et al. Radiation therapy dosimetry using magnetic resonance imaging of polymer gels Med. phys. AAPM. 23:5. 1996.

3. Day M, Stein G. Chemical effects of ionizing radiation in some gels Nature. 166:146–7. 1950.

4. Gore JC, Kang YS. Measurement of radiation dose distributions by nuclear magnetic resonance (NMR) imaging. Phys Med Biol. 29(10):1189–97. 1984.

5. Swallow AJ. Radiation Chemistry: An Introduction: Longman, London. 1973.

6. Magee JL., Chatterjee A.Track reactions of radiation chemistry in: Kinetics of Nonhomogeneous Processes: GR Freeman, John Wiely and Sons, New York. 1987.

7. Deene Y. D., Hurley C., Venning A., et al. A basic study of some normoxic polymer gel dosimeters Phys. Med. Biol. 47:3441. 2002.

8. Haraldsson P., Karlsson A., Wieslander E., et al. Dose response evaluation of a low-density normoxic polymer gel dosimeter using MRI Phys. Med. Biol. 51:919. 2006.

9. Jirasek A., Hilts M., McAuley K. B.Polymer gel dosimeters with enhanced sensitivity for use in x-ray CT polymer gel dosimetry. Phys. Med. Biol. 21:5269. 2010.

10. Cho Woong, Lee Jaegi, Kim Hyun Suk, et al. Development of Quality Assurance Softwarefor PRESAGEREU Gel Dosimetry. PROGRESS in MEDICAL PHYSICS Vol. 25, No. 4, December. 2014.

11. Grant RL, Crowder ML, Ibbott GS, et al. Three dimensional dosimetry of a beta-emitting radionuclide using PRESAGE dosimeters. J Phys: Conf Ser. 250(1):2010.

12. Zhao L, Newton J, Oldham M, et al. Feasibility of using PRESAGEⓇ for relative 3D dosimetry of small proton fields. Phys Med Biol. 57(22):N431–43. 2012.

13. Zhao L, Das IJ, Zhao Q, Thomas A, et al. Determination of the depth dose distribution of proton beam using PRESAGETM dosimeter. J Phys: Conf Ser. 250(1):012035. 2010.

14. Doran SJ. .:. The history and principles of chemical dosimetry for 3-D radiation fields: Gels, polymers and plastics. Appl Radiat Isot. 67(3):393–8. 2009.

15. Jordan K, Avvakumov N. .:. Radiochromic leuco dye micelle hydrogels: I. Initial investigation. Phys Med Biol. 54(22):6773–89. 2009.

16. Lee Sang Hoon, Sim Su Jung, Chang Kyung Hwan, et al. Physical and Radiological Properties of Radiochromic gel as of Its composition. Journal of the Korean Physical society, vol 64. 2013.

17. Babic S, Battista J, Jordan K. Radiochromic leuco dye micelle hydrogels: II. Low diffusion rate leuco crystal violet gel. Phys Med Biol. 54(22):6791–808. 2009.

Fig. 1.

The wavelength spectra of reusable LMG micelle gel for various doses. Peak sensitivity was marked at the wavelength of 630~635 nm.

Fig. 2.

The dose absorbance curves of various reusable LMG and LCV compounds.

Fig. 3.

Comparisions of the dose sensitivity of reusable LMG with that of LCV.

Fig. 4.

The dose response curve of reusable LMG measured as their absorbances (It containes 0.37 mM Reusable LMG, 16 mM TCAA, 7 mM Triton x-100 and 4% w/w gelatin).

Table 1.

Different gel groups for research reusable LMG and LCV composition.

	Gelatin (Wt.%)	LMG	LCV	CCl₃COOH (mM)	Triton X-100 (mM)
Group 1	4	0.5	-	16	7
Group 2	4	0.5	-	20	7
Group 3	4	0.5	-	30	7
Group 4	4	0.37	-	16	7
Group 5	4	0.6	-	16	7
Group 6	4	1	-	16	7
Group 7	4	0.5	-	16	4
Group 8	4	0.5	-	16	2
Group 9	4	-	1	30	8

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