Development of Dual-mode Signal Processing Module for Multi-slit Promptgamma Camera

Jong Hoon Park; Han Rim Lee; Sung Hun Kim; Chan Hyeong Kim; Dong Ho Shin; Se Byeong Lee; Jonh Hwi Jeong

doi:10.14316/pmp.2016.27.1.37

Journal List > Prog Med Phys > v.27(1) > 1098511

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Park, Lee, Kim, Kim, Shin, Lee, and Jeong: Development of Dual-mode Signal Processing Module for Multi-slit Promptgamma Camera

Original Article

Progress in Medical Physics 2016;27(1):37-45.

Published online: 4 March 2016

DOI: https://doi.org/10.14316/pmp.2016.27.1.37

Development of Dual-mode Signal Processing Module for Multi-slit Promptgamma Camera

Jong Hoon Park^*, Han Rim Lee^*,^†, Sung Hun Kim^*,^‡, Chan Hyeong Kim^*,^‡,, Dong Ho Shin^†, Se Byeong Lee^‡, Jonh Hwi Jeong^‡

^*Department of Nuclear Engineering, Hanyang University, Seoul, Korea

^†IT Convergence Technology Research Laboratory, Electronics and Telecommunications Research Institute, Daejeon, Korea

^‡ Proton Therapy Center, National Cancer Center, Goyang, Korea

Correspondence:Chan Hyeong Kim (chkim@hanyang.ac.kr) Tel:82-2-2220-0513, Fax:82-2-2220-4059

Received 15 March 2016 Revised 25 March 2016 Accepted 28 March 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In proton therapy, in vivo proton beam range verification is very important to deliver conformal dose to the target volume and minimize unnecessary dose to normal tissue. For this purpose, a multi-slit prompt-gamma camera module made of 24 scintillation detectors and 24-channel signal processing system is under development. In the present study, we have developed and tested a dual-mode signal processing system, which can operate in the energy calibration mode and the fast data acquisition mode, to process the signals from the 24 scintillation detectors. As a result of performance test, using the energy calibration mode, we were able to perform energy calibration for the 24 scintillation detectors at the same time and determine the discrimination levels for the detector channels. Further, using the fast data acquisition mode, we were able to measure a prompt-gamma distribution induced by a 45 MeV proton beam. The measured prompt gamma distribution was found similar to the proton dose distribution at the distal fall-off region, and the estimated beam range was 17.13±0.76 mm, which is close to the proton beam range of 16.15 mm measured by an EBT film.

Keywords: Proton therapy, Multi-slit prompt-gamma camera, Multi-slit collimator, Scintillation detector array, Dual-mode signal processing module

References

1. Paganetti H. Rangeuncertaintiesinprotontherapyandthe roleofMonteCarlosimulations.Phys.Med.Biol. 57:R99–R117. 2012.

2. Knopf AC, Lomax A. Invivoprotonrangeverification: a review.Phys.Med.Biol. 58:R131–R160. 2012.

3. Stichelbaut F, Jongen Y. Verificationoftheprotonbeam positioninthepatientbythedetectionofpromptgamma-rays emission. Meetingof39thParticleTherapyCo-OperativeGroup. (San Francisco,. 2003.

4. Min CH, Kim CH, Youn MY, Kim JW. Promptgamma measurementsforlocatingthedosefall-offregionintheproton therapy.Appl.Phys.Lett. 89:183517. 2006.

5. Smeets J, Roellinghoff F, Prieels D, Stichelbaut F, Benilov A, Busca P, Fiorini C, Peloso R, Basilavecchia M, Frizzi T, Dehaes JC Dubus A. Promptgammaimaging withaslitcameraforreal-timerangecontrolinprotontherapy. Phys.Med.Biol. 57:3371–3405. 2012.

6. Bom V, Joulaeizadeh L, Beekman F. Real-timeprompt gammamonitoringinspot-scanningprotontherapyusingimagingthroughaknife-edge-shapedslit.Phys.Med.Biol. 57:297–308. 2012.

7. Perali I, Celani A, Bombelli L, Fiorini C, Camera F, Clementel E, Henrotin S, Janssens G, Prieels D, Roellinghoff F, Smeets J, Stichelbaut F, Stappen FV. Promptgammaimagingofprotonpencilbeamsatclinicaldose rate.Phys.Med.Biol. 59:5849–5871. 2014.

8. Priegnitz M, Helmbrecht S, Janssens G, Perali I, Smeets J, Stappen FV, Sterpin E, Fiedler F. Detection ofmixed-rangeprotonpencilbeamswithapromptgammaslit camera.Phys.Med.Biol. 61:855–871. 2016.

9. Frandes M, Zoglauer A, Maxim V, Prost R. Atracking Compton-scatteringimagingsystemforhadrontherapy monitoring.IEEETrans. Nuc.Sci. 57:144–150. 2010.

10. Richard MH, Chevallier M, Dauvergne D, Freud N, Henriquet P, Le Foulher, Letang JM, Montarou G, Ray C, Roellinghoff F, Testa E, Testa M, Walenta AH. DesignguidelinesforadoublescatteringComptoncamerafor prompt-gammaimagingduringionbeamtherapy: aMonte Carlosimulationstudy.IEEETrans.Nuc.Sci. 58:87–94. 2011.

11. Polf JC, Avery S, Mackin DS, Beddar S. Evaluationofa stochasticreconstructionalgorithmforuseinComptoncamera imagingandbeamrangeverificationfromsecondarygamma emissionduringprotontherapy.Phys.Med.Biol. 57:3537–3553. 2012.

12. Krimmer J, Ley JL, Abellan C, Cachemiche JP, Caponetto L, Chen X, Dahoumane M, Dauvergne D, Freud N, Joly B, Lambert D, Lestand L, Letang JM, Magne M, Mathez H, Maxim V, Montarou G, Morel C, Pinto M, Ray C, Reithinger V, Testa E, Zoccarato Y. DevelopmentofaComptoncameraformedicalapplications basedonsiliconstripandscintillationdetectors.Nucl.Instrum. Meth.A. 787:98–101. 2014.

13. Mackin D, Peterson S, Beddar S, Polf JC. Imagingof promptgammaraysemittedduringdeliveryofclinicalproton beamswithaComptoncamera: Feasibilitystudiesforrange verification.Phys.Med.Biol. 60:7085–7099. 2015.

14. Kim CH, Park JH, Seo H, Lee HR. Gammaelectronvertex imaingandapplicationtobeamrangeverificationinproton therapy.Med.Phys. 39:1001–1005. 2012.

15. Lee HR, Park JH, Kim JH, Jung WG, Kim CH. Developmentofsignalprocessingmodulesfordouble-sidedsil-iconstripdetectorofgammaverteximagingforprotonbeam doseverification.J.Radiat.Prot. 39(2):81–88. 2014.

16. Golnik C, Hueso-Gonzalez F, Muller A, Dendooven P, Enghardt W, Fiedler F, Kormoll T, Roemer K, Petzoldt J, Wagner A, Pausch G. Rangeassessmentinparticletherapybasedonpromptγ-raytimingmeasurements.Phys.Med. Biol. 59:5399–5422. 2014.

17. Hueso-Gonzalez F, Enghardt W, Fiedler F, Golnik C, Janssens G, Petzoldt J, Prieels D, Priegnitz M, Romer K, Smeets J. Firsttestofthepromptgammaraytimingmeth-odwithheterogeneoustargetsataclinicalrotontherapyfacility. Phys.Med.Biol. 60:6247–6272. 2015.

18. Min CH, Lee HR, Kim CH, Lee SB. Developmentofar-ray-typepromptgammameasurementsystemforinvivorange verificationinprotontherapy.Med.Phys. 39:2100–2107. 2012.

19. 이한림, 박종훈, 김한성, 김찬형. 다채널 방사선 측정 장치의 데이터 획득 채널수 저감을 위한 멀티플렉싱 시스템 개발.2013춘계학술발표회 논문요약집 대한방사선방어학회. 140-141:2013.

Fig. 1.

Schematic diagram of 24- channel front-end electronics system including charge sensitive amplifiers and slow and fast shaping amplifiers.

Fig. 2.

Schematic diagram of multiplexing system for energy calibration mode.

Fig. 3.

Schematic diagram of counting system for fast data acquisition mode.

Fig. 4.

Assembled dual-mode signal processing system including pream-plifiers, shapers, a multiplexing system, pulse height discrimina-tors, a microcontroller (Arduino), an Xbee.

Fig. 5.

A scintillation detector (left) and an array of 24-channel scintillation detectors (right).

Fig. 6.

Experiment setting to measure prompt gamma from a 45 MeV proton beam.

Fig. 8.

Energy calibration curves for the 24 channels of the signal processing system.

Fig. 7.

Energy spectra of mode of the dual-mode signal processing system developed in the present study.¹33 Ba (356 keV), ²2 Na (511 keV, 1,275 keV), ¹37 Cs (662 keV) sources measured by the energy calibration

Fig. 9.

Proton dose distribution (left) and its profile (right) measured by an EBT film.

Fig. 10.

Promptgamma distribution measured by the multi-slit prompt-gamma camera in the fast data acquisition mode for a 45 MeV proton beam of 3×10¹⁰ protons. The film measured proton dose distribution is shown for comparison.

Fig. 11.

Promptgamma distribution measured by the multi-slit prompt-gamma camera in the fast data acquisition mode for a 45 MeV proton beam of 3×10⁹ protons. The film measured proton dose distribution is shown for comparison.

TOOLS

Similar articles