Preliminary Study for Imaging of Therapy Region from Boron Neutron Capture Therapy

Joo-Young Jung; Do-Kun Yoon; Seong-Min Han; HongSeok Jang; Tae Suk Suh

doi:10.14316/pmp.2014.25.3.151

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Jung, Yoon, Han, Jang, and Suh: Preliminary Study for Imaging of Therapy Region from Boron Neutron Capture Therapy

Original Article

Progress in Medical Physics 2014;25(3):151-156.

Published online: 20 September 2014

DOI: https://doi.org/10.14316/pmp.2014.25.3.151

Preliminary Study for Imaging of Therapy Region from Boron Neutron Capture Therapy

Joo-Young Jung^∗,^†, Do-Kun Yoon^∗,^†, Seong-Min Han^‡, HongSeok Jang^§, Tae Suk Suh^∗,^†,

^∗Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea

^†Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea

^‡Department of Health Science, School of Child and Social Welfare, The Kyungwoon University of Korea, Gumi, Korea

^§Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea

Correspondence:Tae Suk Suh(suhsanta@catholic.ac.kr) Tel:82-2-2258-7232, Fax:82-2-2258-7506

This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technologies (ICT)&Future Planning (MSIP) (Grant No. 2009–00420) and the Radiation Technology R&D program (Grant No. 2013M2A2A7043498), Republic of Korea.

Received 7 July 2014 Revised 31 July 2014 Accepted 7 August 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to confirm the feasibility of imaging of therapy region from the boron neutron capture therapy (BNCT) using the measurement of the prompt gamma ray depending on the neutron flux. Through the Monte Carlo simulation, we performed the verification of physical phenomena from the BNCT; (1) the effects of neutron according to the existence of boron uptake region (BUR), (2) the internal and external measurement of prompt gamma ray dose, (3) the energy spectrum by the prompt gamma ray. All simulation results were deducted using the Monte Carlo n-particle extended (MCNPX, Ver.2.6.0, Los Alamos National Laboratory, Los Alamos, NM, USA) simulation tool. The virtual water phantom, thermal neutron source, and BURs were simulated using the MCNPX. The energy of the thermal neutron source was defined as below 1 eV with 2,000,000 n/sec flux. The prompt gamma ray was measured with the direction of beam path in the water phantom. The detector material was defined as the lutetium-yttrium oxyorthosilicate (Lu0,6Y1,4Si0,5:Ce; LYSO) scintillator with lead shielding for the collimation. The BUR's height was 5 cm with the 28 frames (bin: 0.18 cm) for the dose calculation. The neutron flux was decreased dramatically at the shallow region of BUR. In addition, the dose of prompt gamma ray was confirmed at the 9 cm depth from water surface, which is the start point of the BUR. In the energy spectrum, the prompt gamma ray peak of the 478 keV was appeared clearly with full width at half maximum (FWHM) of the 41 keV (energy resolution: 8.5%). In conclusion, the therapy region can be monitored by the gamma camera and single photon emission computed tomography (SPECT) using the measurement of the prompt gamma ray during the BNCT.

Keywords: BNCT, Neutron flux, Prompt gamma ray, Monte Carlo, MCNPX

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Fig. 1.

Change of the neutron flux depending on the depth of the phantom. (a) The neutron flux according to the depth from the water phantom without boron uptake region (BUR), (b) The neutron flux according to the depth from the water phantom with boron uptake region (BUR), (c) the change of the neutron flux from the BUR.

Fig. 2.

Percentage depth dose of the prompt gamma ray from the phantom; (a) the external detection using the detector, (b) in-vivo dosimetry using the simulation.

Fig. 3.

Energy spectrum including the prompt gamma ray peak of the 478 keV with the full width at half maximum of the 41 keV (energy resolution: 8.5%).

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