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Abstract
Endocrine disrupting chemicals (EDCs) are exogenous chemicals contained in industrial substances and plasticizers commonly utilized worldwide. Human exposure to such chemicals, particularly at low-doses, is omnipresent, persistent, and occurs in complex mixtures. EDCs include bisphenol A, phthalates, pesticides, and persistent organic pollutants such as polychlorinated biphenyls. Burgeoning epidemiological, animal, and cellular data link environmental EDCs to metabolic dysfunction. In the last three decades, the number of diabetic patients has drastically increased worldwide, with current statistics suggesting that the number will double in the next two decades. There is epidemiological and experimental evidence linking background exposure to a selection of environmental EDCs with diabetes and impaired glucose metabolism. EDC may be related to increased risk of diabetes.
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