Thyroid Metastasis from Colon Cancer: a Case Report

Dong-il Kim; Youn Joo Jung; Hyun Yul Kim; Hyun-june Paik; Jee Yeon Kim

doi:10.16956/jes.2018.18.2.167

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Kim, Jung, Kim, Paik, and Kim: Thyroid Metastasis from Colon Cancer: a Case Report

Short Communication

J Endocr Surg. 2018;18(2):167-170.

Published online: 5 June 2018

DOI: https://doi.org/10.16956/jes.2018.18.2.167

Thyroid Metastasis from Colon Cancer: a Case Report

Dong-il Kim¹

, Youn Joo Jung¹

, Hyun Yul Kim³

, Hyun-june Paik¹

, Jee Yeon Kim²

¹Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea

²Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Korea

³Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea

Correspondence to Hyun Yul Kim Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20 Geumo-ro, Yangsan 50612, Korea. E-mail: isepa102@naver.com

Received 28 May 201817 June 2018 Accepted 19 June 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

초록

Thyroid metastasis from colon cancer is very rare and the prognosis is very poor. We present a rare case of thyroid metastasis from descending colon cancer. A 50-year-old man was visited because of palpable neck mass. He was diagnosed stage III colon cancer 51 months before symptom presentation. He has also underwent palliative chemotherapy and radiotherapy for distant metastasis of colon cancer. Imaging study showed a left side deviation of trachea due to 3.3 cm sized right thyroid gland mass which was suspicious of metastasis. The patient underwent right thyroid lobectomy. Histopathologic examination and immunohistochemistry revealed adenocarcinoma which was consistent with a diagnosis of metastases from primary colon cancer to the thyroid gland. Surgeon should consider the operation that distant metastasis to the thyroid gland is possible among the patients who present compression symptom on the neck.

Keywords: Colon cancer, Metastasis, Thyroid gland

REFERENCES

1.Lièvre A., Leboulleux S., Boige V., Travagli JP., Dromain C., Elias D, et al. Thyroid metastases from colorectal cancer: the Institut Gustave Roussy experience. Eur J Cancer. 2006. 42:1756–9.

2.Shimaoka K., Sokal JE., Pickren JW. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer. 1962. 15:557–65.

3.Calzolari F., Sartori PV., Talarico C., Parmeggiani D., Beretta E., Pezzullo L, et al. Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study. Anticancer Res. 2008. 28:2885–8.

4.Chung AY., Tran TB., Brumund KT., Weisman RA., Bouvet M. Metastases to the thyroid: a review of the literature from the last decade. Thyroid. 2012. 22:258–68.

5.Montero PH., Ibrahimpasic T., Nixon IJ., Shaha AR. Thyroid metastasectomy. J Surg Oncol. 2014. 109:36–41.

6.Froylich D., Shiloni E., Hazzan D. Metachronous colon metastasis to the thyroid: a case report and literature review. Case Rep Surg. 2013. 2013:241678.

7.Nixon IJ., Whitcher M., Glick J., Palmer FL., Shaha AR., Shah JP, et al. Surgical management of metastases to the thyroid gland. Ann Surg Oncol. 2011. 18:800–4.

8.Kumamoto K., Utsumi Y., Sugano K., Hoshino M., Suzuki S., Takenoshita S. Colon carcinoma metastasis to the thyroid gland: report of a case with a review of the literature. Tumori. 2006. 92:252–6.

9.Bong J., Cho C., Park S. Metastasis to the thyroid gland in patients with metachronous rectal carcinoma and adenocarcinoma of the lungs. J Korean Surg Soc. 2009. 76:392–7.

10.Park HS., Hong JC. A case of thyroid metastasis from pulmonary adenocarcinoma. Korean J Endocr Surg. 2011. 11:179–81.

Fig. 1.

PET/CT shows conglomerated hypermetabolic activity involving right thyroid lobe and paratracheal LNs. PET = positron emission tomography; CT = computed tomography; LN = lymph node.

Fig. 2.

CT neck shows hypodense nodule at right thyroid gland with left side deviation of trachea. CT = computed tomography.

Fig. 3.

(A) Metastatic tumor cell nests showed nuclear positivity for CDX2 immunostaining, (B) metastatic tumor cell nests are negative for TTF-1 immunostaining, and (C) metastatic tumor cell nests are negative for Tg immunostaining (immunohistochemical staining, ×200). TTF-1 = thyroid-transcription-factor 1; Tg = thyroglobulin.

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