Comparison of Mean Optic Disc Cup Surface Depth between Primary Open-angle Glaucoma and Glaucoma-like Disc

Yong Seok Mun; Ahnul Ha; Jin Wook Jeoung; Ki Ho Park; Young Kook Kim

doi:10.3341/jkos.2018.59.6.556

Journal List > J Korean Ophthalmol Soc > v.59(6) > 1096567

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Mun, Ha, Jeoung, Park, and Kim: Comparison of Mean Optic Disc Cup Surface Depth between Primary Open-angle Glaucoma and Glaucoma-like Disc

Original Article

Journal of the Korean Ophthalmological Society 2018; 59(6): 556-560.

Published online: 15 June 2018

DOI: https://doi.org/10.3341/jkos.2018.59.6.556

Comparison of Mean Optic Disc Cup Surface Depth between Primary Open-angle Glaucoma and Glaucoma-like Disc

Yong Seok Mun, MD, Ahnul Ha, MD, Jin Wook Jeoung, MD, PhD, Ki Ho Park, MD, PhD, Young Kook Kim, MD

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Address reprint requests to Young Kook Kim, MD. Department of Ophthalmology, Seoul National University Hospital, #101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: 82-2-2072-4301, Fax: 82-2-741-3187, md092@naver.com

Received 7 December 2017 Revised 11 March 2018 Accepted 4 June 2018

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Optic nerve head surface depression in patients with glaucoma has been previously reported. We quantitatively compared the mean optic disc cup surface depth between glaucoma-like disc (GLD) patients with large cup-to-disc ratios and primary open-angle glaucoma (POAG) patients.

Methods

A total of 40 eyes of 40 patients with GLD and 40 eyes of 40 patients with POAG were included in this study. All patients had an average cup-to-disc ratio of 0.7–0.8. The optic disc area, mean cup-to-disc ratio, and mean optic disc cup volume were measured using spectral domain optical coherence tomography (Cirrus™ HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA, USA). The mean optic disc cup surface depth was calculated using the formula: (mean optic disc cup volume/[optic disc area × mean cup-to-disc ratio²]) − 200 µm.

Results

The mean ages of patients were 61.18 ± 11.83 and 59.65 ± 11.69 years for the GLD and POAG groups, respectively. The average cup-to-disc ratios were 0.74 ± 0.03 and 0.75 ± 0.03 for the GLD and POAG groups, respectively, but no significant difference was observed between the two groups. The mean optic disc cup surface depths were 144.74 ± 82.78 µm and 199.53 ± 90.26 µm for the GLD and POAG groups, respectively, and the difference between the two groups was statistically significant (p = 0.006, t-test).

Conclusions

POAG patients showed a significantly greater mean optic disc cup surface depth compared to GLD patients with a similar mean cup-to-disc ratio. Based on the results of spectral domain optical coherence tomography, confirming the mean optic disc cup surface depth is expected to provide additional information to distinguish GLD from POAG patients.

Keywords: Cup depth, Glaucoma-like disc, Optic disc, Optical coherence tomography

Figures and Tables

Table 1

Comparison of demographic and baseline clinical characteristics between glaucoma-like disc and primary open-angle glaucoma patients

Values are presented as mean ± SD unless otherwise indicated.

IOP = intraocular pressure; SE = spherical equivalent; CCT = central corneal thickness.

^*Student t-test; ^†Chi-square test.

Table 2

Comparison of spectral-domain optical coherence tomography measurements between glaucoma-like disc and primary open-angle glaucoma patients

Values are presented as mean ± SD unless otherwise indicated.

RNFL = retinal nerve fiber layer.

^*Student t-test.

Notes

This study was presented as an e-poster at the 119th Annual Meeting of the Korean Ophthalmological Society 2018.

^{Conflicts of Interest} The authors have no conflicts to disclose.

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