Journal List > J Korean Ophthalmol Soc > v.59(6) > 1096564

J Korean Ophthalmol Soc. 2018 Jun;59(6):537-542. Korean.
Published online June 15, 2018.  https://doi.org/10.3341/jkos.2018.59.6.537
©2018 The Korean Ophthalmological Society
Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography in Healthy Koreans
Youna Choi, MD and Byung Joo Cho, MD, PhD
Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Korea.

Address reprint requests to Byung Joo Cho, MD, PhD. Department of Ophthalmology, Konkuk University Medical Center, #120-1 Neungdong-ro, Gwangjin-gu, Seoul 05030, Korea. Tel: 82-2-2030-8180, Fax: 82-2-2030-5273, Email: bjcho@kuh.ac.kr
Received July 20, 2017; Revised March 31, 2018; Accepted May 28, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

To determine normal retinal nerve fiber layer (RNFL) thickness by age and to investigate the relationships of the RNFL with clinical variables using spectral domain optical coherence tomography (SD-OCT) in healthy Koreans.

Methods

The peripapillary RNFL thicknesses were measured around the optic disc using consecutive circular B-scans with 3.5 mm diameter and automatically calculated using a SD-OCT.

Results

Three hundreds fifty-two eyes of 205 healthy subjects were included in the study and RNFL thickness were measured by SD-OCT. Overall average RNFL thickness was 100.2 ± 10.9 µm, and significantly and negatively correlated with age (r = −0.164, p = 0.002). The overall average RNFL thickness decrease per decade was 0.8 µm (95% confidence interval, −0.3 to −1.3, p = 0.019). Mean RNFL thickness of each quadrant was significantly correlated with axial length except in the superior quadrant.

Conclusions

This study describes the normal RNFL thickness values of Koreans as determined by SD-OCT. Furthermore, age was found to be correlated with normal RNFL thickness, however age-related changes were not uniform across every region.

Keywords: Axial length; Cup-to-disc ratio; Korean; Retinal nerve fiber layer; Spectral domain optical coherence tomography

Figures


Figure 1
Associations between overall retinal nerve fiber layer (RNFL) thickness and age. Age significantly affected overall average RNFL thickness, and the rate of average RNFL thinning was approximately 0.8 µm per decade. dots mean individual RNFL thickness for age, line mean RNFL thickness average.
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Figure 2
The associations between retinal nerve fiber layer (RNFL) thickness and axial length (AXL). AXL significantly affected average RNFL thickness in four quadrants. RNFL thicknesses in superior, nasal, and inferior quadrants decreased and RNFL thickness in temporal quadrant increased as AXL increased. dots mean RNFL thickness for AXL, lines are presented as mean RNFL thickness. T = temporal; S = superior; N = nasal; I = inferior.
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Tables


Table 1
Characteristics of subjects
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Table 2
Mean retinal nerve fiber layer thicknesses of each segment by age
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Table 3
Correlation between RNFL thickness in each region and clinical variables
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Table 4
Multiple linear regression analysis for the relationship of age with RNFL thickness in each region
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Table 5
Multiple linear regression analysis for the relationship of axial length with RNFL thickness in each region
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Notes

Conflicts of Interest:The authors have no conflicts to disclose.

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