Journal List > Korean J Pediatr Infect Dis > v.21(3) > 1096430

Bae, Song, Kim, Son, and Park: A Study on Clinical Manifestations of Pulmonary Tuberculosis and Tuberculosis Contact Investigation in School-Age Children and Adolescents at Two Centers

Abstract

Purpose

The aim of this study was to evaluate the clinical manifestations, contact history, and status of tuberculosis contact investigations in school-age children and adolescents with pulmonary tuberculosis (TB) at two centers.

Methods

This study was conducted with 54 patients in the age ranging from 10 to 18 years, who were diagnosed with pulmonary TB at the Pusan National University Hospital and Pusan National University Children's Hospital, January 2008 to December 2012. We retrospectively reviewed the medical records of the patients.

Results

The median age of the patients was 16 years old; 11 patients were aged 10 to 14 and 43 patients were aged 15 to 18. Among 54 patients, 19 had history of contact with pulmonary TB, 10 had contact with house members (household), and remaining 9 had contact with classmates (non-household). One out of 10 patients who had household contacts and 6 out of 9 patients who had non-household contacts were evaluated with contact investigation after the exposure to pulmonary TB. Among 7 patients who were evaluated with contact investigation, 3 were diagnosed with active pulmonary TB, 1 had latent tuberculosis infection (LTBI), and 3 had no evidence of TB or LTBI. The median period of diagnosis after the exposure to active pulmonary TB was 2 years in patients with household contacts and 0.23 years in patients with non-household contacts.

Conclusion

This study suggested that if the contact investigation conducted properly, it would be helpful for early diagnosis and prevention of pulmonary TB.

Figures and Tables

Table 1

Clinical Characteristics of the School-Aged Children and Adolescents with Pulmonary Tuberculosis

kjpid-21-191-i001

Abbreviation: TB, tuberculosis.

Table 2

Comparison of Microbiologic Data in Specimens Obtained by Expectorated Sputum and Bronchoaveolar Lavage

kjpid-21-191-i002

Abbreviation: BAL, bronchoalveolar lavage.

References

1. World Health Organization. Global tuberculosis report. 2013.
2. Choi KM, Kim NH, Kim DH, Kim YJ, Kim JH, Oh SH, et al. Korean guidelines for diagnosis and treatment of tuberculosis in children and adolescents. Korean J Pediatr Infect Dis. 2011; 18:1–14.
3. Joint Committee for the Development of Korean Guidelines for Tuberculosis Korea Centers for Disease Control and Prevention. Korean guidelines for tuberculosis. 2011.
4. Korea Center for Disease Control and Prevention. Korean Institute of Tuberculosis. Korean National Tuberculosis Association. 2012 annual report on the notified tuberculosis patient in Korea (based on tuberculosis surveillance system). Korea Center for Disease Control and Prevention. 2013; 10-1:34.
5. Pediatric Tuberculosis Collaborative Group. Targeted tuberculin skin testing and treatment of latent tuberculosis infection in children and adolescents. Pediatrics. 2004; 114:1175–1201.
6. Joint Committee for the Development of Korean Guidelines for Tuberculosis Korea Centers for Disease Control and Prevention. Korean guideline for tuberculosis, 2005. 2005. p. 80–81.
7. Cohn DL, O'Brien RJ, Geiter LJ, Gordin F, Hershfield E, Horsburgh C. Targeted tuberculin testing and treatment of latent tuberculosis infection. MMWR Morb Moral Wkly Rep. 2000; 49:1–54.
8. Choi JW, Kim MS, Kim JH. Comparison of results between tuberculin skin test and QuantiFERONγ-TB intube assay for diagnosis of latent tuberculosis infection in children and adolescents. Korean J Pediatr Infect Dis. 2013; 20:17–27.
9. Eun BW. Characteristics of tuberculosis in children and adolescents. Korean J Pediatr. 2009; 52:513–518.
10. Cruz AT, Hwang KM, Birnbaum GD, Starke JR. Adolescents with tuberculosis: A review of 145 cases. Pediatr Infect Dis J. 2013; 32:937–941.
11. Lawson L, Yassin MA, Thacher TD, Olatunji OO, Lawson JO, Akingbogun TI, et al. Clinical presentation of adults with pulmonary tuberculosis with and without HIV infection in Nigeria. Scand J Infect Dis. 2008; 40:30–35.
12. Eun B, Moon JS, Eun S, Lee HK, Shin SM, Sung IK, et al. The current child and adolescent health screening system: An assessment and proposal for an early and periodic check-up program. Korean J Pediatr. 2010; 53:300–306.
13. McWilliams T, Wells AU, Harrison AC, Lindstrom S, Cameron RJ, Foskin E. Induced sputum and bronchoscopy in the diagnosis of pulmonary tuberculosis. Thorax. 2002; 57:1010–1014.
14. Anderson C, Inhaber N, Menzies D. Comparison of sputum induction with fiber-optic bronchoscopy in the diagnosis of tuberculosis. Am J Respir Crit Care Med. 1995; 152:1570–1574.
15. Conde MB, Soares SL, Mello FC, Rezende VM, Almeida LL, Reingold AL, et al. Comparison of sputum induction with fiberoptic bronchoscopy in the diagnosis of tuberculosis: Experience at an acquired immune deficiency syndrome reference center in Rio de Janeiro, Brazil. Am J Respir Crit Care Med. 2000; 162:2238–2240.
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