Journal List > Korean J Pediatr Infect Dis > v.21(3) > 1096428

Korean J Pediatr Infect Dis. 2014 Dec;21(3):174-180. Korean.
Published online December 17, 2014.  https://doi.org/10.14776/kjpid.2014.21.3.174
Copyright © 2014 The Korean Society of Pediatric Infectious Diseases
Clinical and Epidemiological Study of 1,165 Hospitalized Cases of Rotaviral Gastroenteritis Before and After the Introduction of Rotavirus Vaccine, 2006-2013
Tae-Young Sohn, M.D., Chan-Jae Lee, M.D., Yoon-Joo Kim, M.D., Min-Jae Kang, M.D., Sung-Hye Kim, M.D., So-Yeon Lee, M.D., Dae-Hyoung Lee, M.D., Hae-Ran Lee, M.D. and Kwang-Nam Kim, M.D.
Department of Pediatrics, Hallym University Medical Center, Gyeonggi, Korea.

Corresponding author (Email: tsnjs4u@hanmail.net )
Received April 03, 2014; Revised July 11, 2014; Accepted July 14, 2014.

Abstract

Purpose

This study was performed to assess the clinical and epidemiological changes after the introduction of the rotavirus vaccine in Korea, as well as to determine the efficacy of the rotavirus vaccine among hospitalized rotaviral gastroenteritis patients over the past two years.

Methods

We analyzed yearly and seasonal patterns of 1,165 inpatients who were hospitalized for rotaviral gastroenteritis under the age of 5 years between 2006 and 2013. We also conducted a survey among 460 gastroenteritis patients who were hospitalized between 2012 and 2013 regarding the rotavirus vaccination and the symptoms of gastroenteritis. Among those individuals surveyed, clinical indices were analyzed for 124 patients who were tested positive for the rotavirus antigen.

Results

The incidence of Rotaviral gastroenteritis have decreased significantly by year 2010. After the introduction and widespread dissemination of the rotavirus vaccine, the onset of the disease and the seasonal peak have been delayed. Overall, the vaccinated group showed a lower rate of positivity than the unvaccinated group. Among the hospitalized rotaviral gastroenteritis patients, the vaccinated group had a shorter hospitalization period, less severe clinical symptoms of gastroenteritis, and better laboratory test results.

Conclusions

After introduction of the rotavirus vaccine in Korea, there were two main trends observed: 1) the overall level of disease incidence was reduced; 2) the severity of rotaviral gastroenteritis cases also decreased. Based on this data, more children should receive vaccination in order to prevent the rotavirus infection and decrease the severity of rotaviral gastroenteritis.

Keywords: Rotavirus; Gastroenteritis; Vaccine; Epidemiology

Figures


Fig. 1
Annual percentage of rotaviral gastroenteritis patients out of all gastroenteritis patients (2006–2013).
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Fig. 2
Monthly incidence rate of rotaviral gastroenteritis: (A) 2006–2009, (B) 2010–2013.
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Tables


Table 1
Baseline Demographic and Clinical Comparison between the Vaccinated Group and Unvaccinated Group for Rotaviral Gastroenteritis
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Table 2
Laboratory Results in the Vaccinated Group and Unvaccinated Group for Rotaviral Gastroenteritis
Click for larger image

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