Journal List > Korean J Pediatr Infect Dis > v.21(3) > 1096427

Park and Chung: The Changes in the Outbreak of Rotavirus Gastroenteritis in Children after Introduction of Rotavirus Vaccines: A Retrospective Study at a Tertiary Hospital

Abstract

Purpose

This study aimed to examine the changes in the outbreak of acute gastroenteritis, rotavirus gastroenteritis after the introduction of the rotavirus vaccine in Korea. Methods: The current study investigated the number of inpatients in the pediatric ward of Inje University Sanggye Paik Hospital during the periods of 2005-2006 and 2011-2012. A retrospective analysis was conducted on the medical records of 2,840 patients <5 years of age who were hospitalized at Inje University Sanggye Paik Hospital in these time periods. Results: When we compared 2 separate sets of data from before (2005–2006) and after (2011–2012) vaccine introduction, there were statistically significant decreases in the number of patients who were hospitalized for acute gastroenteritis across all of the groups of patients <5 years of age except those <2 months of age. The number of patients with rotavirus gastroenteritis in all age groups declined except for children <2 months of age and those 2–5 months of age. Conclusion: These results show that after the introduction of a rotavirus vaccine in Korea, the incidence of rotavirus gas-troenteritis decreased in 6–59-month-old patients hospitalized for acute gastroenteritis.

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Fig. 1.
Acute gastroenteritis-related hospitalization.
kjpid-21-167f1.tif
Fig. 2.
Monthly distributions of rotavirus gastroenteritis.
kjpid-21-167f2.tif
Table 1.
Acute Gastroenteritis-related Hospitalization and Rotavirus Gastroenteritis-related Hospitalization by Age Group
  Pre-introduction group (2005–2006) Post-introduction group (2011–2012) P value
2005 2006 2011 2012
Hospitalization   5,318 5,872 5,031 4,753 0.195
Acute gastroenteritis <2 months 163 156 190 123 0.141
  2–5 months 67 106 51 34 0.000
  6–11 months 163 253 110 68 0.000
  12–23 months 199 343 140 59 0.000
  24–59 months 159 235 146 75 0.000
  Total 751 1,093 637 359 0.000
Rotavirus gastroenteritis <2 months 20 63 66 63 0.037
  2–5 months 13 16 10 4 0.064
  6–11 months 57 60 9 5 0.000
  12–23 months 96 145 30 8 0.000
  24–59 months 75 88 52 18 0.000
  Total 291 372 167 98 0.000
Table 2.
Rotavirus Vaccination Coverage among Ro-tavirus Negative Gastroenteritis
  Age Group Number of Patients Vaccination coverage
Number of Vaccinated Patients %
2011 <2 months 124 0 0
  2–5 months 41 1 2
  6–11 months 101 56 55
  12–23 months 110 37 34
  24–59 months 94 10 11
  6–59 months 305 103 34
2012 <2 months 60 0 0
  2–5 months 30 3 10
  6–11 months 63 44 70
  12–23 months 51 18 35
  24–59 months 57 11 19
  6–59 months 171 73 43
Table 3.
Rotavirus Vaccination Coverage among Ro-tavirus Positive Gastroenteritis
  Age Group Number of Patients Vaccination coverage
Number of Vaccinated Patients %
2011 <2 months 66 0 0
  2–5 months 10 0 0
  6–11 months 9 1 11
  12–23 months 30 0 0
  24–59 months 52 3 6
  6–59 months 91 4 4
2012 <2 months 63 0 0
  2–5 months 4 0 0
  6–11 months 5 2 40
  12–23 months 8 4 0
  24–59 months 18 1 6
  6–59 months 31 7 23
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