The Changes in the Outbreak of Rotavirus Gastroenteritis in Children after Introduction of Rotavirus Vaccines: A Retrospective Study at a Tertiary Hospital

Dong Kyu Park; Ju-Young Chung

doi:10.14776/kjpid.2014.21.3.167

Journal List > Korean J Pediatr Infect Dis > v.21(3) > 1096427

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Park and Chung: The Changes in the Outbreak of Rotavirus Gastroenteritis in Children after Introduction of Rotavirus Vaccines: A Retrospective Study at a Tertiary Hospital

Original Article

Korean J Pediatr Infect Dis 2014;21(3):167-173.

Published online: 20 January 2014

DOI: https://doi.org/10.14776/kjpid.2014.21.3.167

The Changes in the Outbreak of Rotavirus Gastroenteritis in Children after Introduction of Rotavirus Vaccines: A Retrospective Study at a Tertiary Hospital

Dong Kyu Park, M.D., Ju-Young Chung, M.D.

Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine

Received 8 September 2014 Revised 23 October 2014 Accepted 24 October 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study aimed to examine the changes in the outbreak of acute gastroenteritis, rotavirus gastroenteritis after the introduction of the rotavirus vaccine in Korea. Methods: The current study investigated the number of inpatients in the pediatric ward of Inje University Sanggye Paik Hospital during the periods of 2005-2006 and 2011-2012. A retrospective analysis was conducted on the medical records of 2,840 patients <5 years of age who were hospitalized at Inje University Sanggye Paik Hospital in these time periods. Results: When we compared 2 separate sets of data from before (2005–2006) and after (2011–2012) vaccine introduction, there were statistically significant decreases in the number of patients who were hospitalized for acute gastroenteritis across all of the groups of patients <5 years of age except those <2 months of age. The number of patients with rotavirus gastroenteritis in all age groups declined except for children <2 months of age and those 2–5 months of age. Conclusion: These results show that after the introduction of a rotavirus vaccine in Korea, the incidence of rotavirus gas-troenteritis decreased in 6–59-month-old patients hospitalized for acute gastroenteritis.

Keywords: Rotavirus, Vaccination, Gastroenteritis

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Fig. 1.

Acute gastroenteritis-related hospitalization.

Fig. 2.

Monthly distributions of rotavirus gastroenteritis.

Table 1.

Acute Gastroenteritis-related Hospitalization and Rotavirus Gastroenteritis-related Hospitalization by Age Group

		Pre-introduction group (2005–2006)		Post-introduction group (2011–2012)		P value
		2005	2006	2011	2012	P value
Hospitalization		5,318	5,872	5,031	4,753	0.195
Acute gastroenteritis	<2 months	163	156	190	123	0.141
	2–5 months	67	106	51	34	0.000
	6–11 months	163	253	110	68	0.000
	12–23 months	199	343	140	59	0.000
	24–59 months	159	235	146	75	0.000
	Total	751	1,093	637	359	0.000
Rotavirus gastroenteritis	<2 months	20	63	66	63	0.037
	2–5 months	13	16	10	4	0.064
	6–11 months	57	60	9	5	0.000
	12–23 months	96	145	30	8	0.000
	24–59 months	75	88	52	18	0.000
	Total	291	372	167	98	0.000

Table 2.

Rotavirus Vaccination Coverage among Ro-tavirus Negative Gastroenteritis

	Age Group	Number of Patients	Vaccination coverage
	Age Group	Number of Patients	Number of Vaccinated Patients	%
2011	<2 months	124	0	0
	2–5 months	41	1	2
	6–11 months	101	56	55
	12–23 months	110	37	34
	24–59 months	94	10	11
	6–59 months	305	103	34
2012	<2 months	60	0	0
	2–5 months	30	3	10
	6–11 months	63	44	70
	12–23 months	51	18	35
	24–59 months	57	11	19
	6–59 months	171	73	43

Table 3.

Rotavirus Vaccination Coverage among Ro-tavirus Positive Gastroenteritis

	Age Group	Number of Patients	Vaccination coverage
	Age Group	Number of Patients	Number of Vaccinated Patients	%
2011	<2 months	66	0	0
	2–5 months	10	0	0
	6–11 months	9	1	11
	12–23 months	30	0	0
	24–59 months	52	3	6
	6–59 months	91	4	4
2012	<2 months	63	0	0
	2–5 months	4	0	0
	6–11 months	5	2	40
	12–23 months	8	4	0
	24–59 months	18	1	6
	6–59 months	31	7	23

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