Epidemiologic Characteristics of Human Bocavirus-Associated Respiratory Infection in Children

Jae Hong Choi; Ji Yeun Paik; Eun Hwa Choi; Hoan Jong Lee

doi:10.14776/kjpid.2011.18.1.61

Journal List > Korean J Pediatr Infect Dis > v.18(1) > 1096093

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Choi, Paik, Choi, and Lee: Epidemiologic Characteristics of Human Bocavirus-Associated Respiratory Infection in Children

Original Article

Korean Journal of Pediatric Infectious Diseases

Korean Journal of Pediatric Infectious Diseases 2011; 18(1): 61-67.

Published online: 29 June 2011

DOI: https://doi.org/10.14776/kjpid.2011.18.1.61

Epidemiologic Characteristics of Human Bocavirus-Associated Respiratory Infection in Children

Jae Hong Choi, M.D., Ji Yeun Paik, M.D., Eun Hwa Choi, M.D., Hoan Jong Lee, M.D.

Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.

Corresponding author (eunchoi@snu.ac.kr)

Received 1 June 2011 Revised 3 June 2011 Accepted 13 June 2010

Abstract

Purpose

This study was performed to investigate the epidemiologic characteristics of human bocavirus (HBoV)-associated lower respiratory tract infections (LRTIs) in children.

Methods

Nasopharyngeal aspirate samples were obtained from 658 children who had been hospitalized for LRTIs in Seoul National University (SNU) Children's Hospital and SNU Bundang Hospital from March 2000 to September 2005. Multiplex RT-PCR was performed to detect 11 respiratory viruses including respiratory syncytial virus, adenovirus, rhinovirus, parainfluenza viruses 1 and 3, influenza viruses A and B, human metapneumovirus, HBoV, human coronavirus (HCoV) OC43/229E, and HCoV-NL63. Clinical data were reviewed retrospectively.

Results

Overall, respiratory viruses were detected in 325 (49.4%) among 658 patients. HBoV was detected in 62 cases (9.4%) and was responsible for 19.1% of virus-positive cases. HBoV was prevalent among infants and young children aged from 3 months to 5 years with the mean age of 25.3 months. Co-detection of HBoV and other respiratory viruses was observed in 37.1% which is significantly higher than average co-detection rate (12.3%) among overall virus-positive cases (P=0.000). HBoV was identified mainly in late spring and early summer from May to July.

Conclusion

This study describes epidemiologic features of HBoV in Korean children compared with those associated with other respiratory viruses. HBoV was prevalent among LRTIs in childhood, especially in late spring and early summer season in Korea.

Keywords: Human bocavirus, Epidemiology, Pneumonia, Bronchiolitis

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