Clinical Manifestation of Human Metapneumovirus Infection in Korean Children

Jung Min Ahn; Seong Yeol Choi; Dong Soo Kim; Ki Hwan Kim

doi:10.14776/kjpid.2013.20.1.28

Journal List > Korean J Pediatr Infect Dis > v.20(1) > 1096047

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Ahn, Choi, Kim, and Kim: Clinical Manifestation of Human Metapneumovirus Infection in Korean Children

Original Article

Korean Journal of Pediatric Infectious Diseases

Korean Journal of Pediatric Infectious Diseases 2013; 20(1): 28-35.

Published online: 30 April 2013

DOI: https://doi.org/10.14776/kjpid.2013.20.1.28

Clinical Manifestation of Human Metapneumovirus Infection in Korean Children

Jung Min Ahn, M.D., Seong Yeol Choi, M.D., Dong Soo Kim, M.D., Ph.D., Ki Hwan Kim, M.D., Ph.D.

Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Korea.

Corresponding author (khkim99@yuhs.ac)

Received 15 September 2012 Revised 22 October 2012 Accepted 22 October 2012

Abstract

Purpose

The aim of this study was to determine the frequency, epidemiology and the clinical manifestation of human metapneumovirus (hMPV) infection in Korean children.

Methods

From February 2010 to January 2012, we collected nasopharyngeal aspiration from 1,554 children who were hospitalized for acute lower respiratory tract infections at the Department of Pediatrics, Severance Children's Hospital. hMPV was detected by performing reverse transcriptase-polymerase chain reaction (RT-PCR). The medical records of the patients with positive results were retrospectively reviewed.

Results

We detected hMPV in 99 of the 1,554 hospitalized children. The mean age of the hMPV infected children was 25 months, and 87% of the illnesses occurred between April and June. The most common diagnoses were pneumonia (73%) and bronchiolitis (16%). The clinical manifestations included cough, fever, respiratory distress, hoarseness, tachypnea, and wheezing. Coinfection with other respiratory viruses was found in 43 children (43%).

Conclusion

hMPV is one of the major virus causing acute respiratory tract infection in the age between 13 months and 48 months old with peaks during April to June. Reports of hMPV in Korea has been increasing but additional studies are required to define the epidemiology and the extent of disease caused by hMPV to determine future development of this illness in Korean children.

Keywords: Metapneumovirus, Respiratory tract infection, Korea, children

Figures and Tables

Fig. 1

Age distribution of the patients with human metapneumovirus infection.

Fig. 2

The human metapneumovirus had the peak at May of 2010, 2011.

Fig. 3

Diagnosis distribution of the patients with human metapneumovirus infection by age.

Table 1

Comparison of Clinical Characteristics between Human Metapneumovirus Infection and Other Virus Infection

Abbreviations : hMPV, human metapneumovirus; WBC, white blood cell; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase

Table 2

Clinical Characteristics of hMPV Infection by Age

Abbreviations : hMPV, human metapneumovirus; WBC, white blood cell; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase

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