Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution

Jae Won Choi; Hyun Jun Cho; Hwang Min Kim; Seok Hahn

doi:10.14776/kjpid.2014.21.1.1

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Choi, Cho, Kim, and Hahn: Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution

Original Article

Korean Journal of Pediatric Infectious Diseases 2014; 21(1): 1-8.

Published online: 23 April 2014

DOI: https://doi.org/10.14776/kjpid.2014.21.1.1

Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution

Jae Won Choi, M.D., Hyun Jun Cho, M.D., Hwang Min Kim, M.D., Ph.D., Seok Hahn, M.D.^*

Department of Pediatrics, Yonsei University, Wonju College of Medicine, Wonju, Korea.

^*Department of Radiology, Yonsei University, Wonju College of Medicine, Wonju, Korea.

Corresponding author (hinear@naver.com)

Received 16 July 2013 Revised 24 October 2013 Accepted 24 October 2013

Abstract

Purpose

The aim for this study was to investigate clinical manifestation of seasonal influenza A and B during the 2012 winter season in Wonju, South Korea. Their clinical and laboratorial characteristics and effect of oseltamivir were compared and analyzed.

Methods

Children under the age of 18 years who visited the Wonju Severance Christian Hospital with fever or acute respiratory symptoms and who were diagnosed with influenza A or B by rapid antigen test from nasopharyngeal swab were selected for the study. The medical records of patients were retrospectively reviewed.

Results

Influenza A was detected in 374 patients (83.7%), and influenza B in 72 (16.6%). The incidence of influenza A was highest in February (n=186), while that of influenza B was highest in March (n=36). The most common symptoms were fever (n=434, 97.1%) and cough (n=362, 81.0%). No significant differences were observed between influenza A and B in symptoms and laboratory data. Patients who had used oseltamivir within 2 days showed statistically lower admission rate, shorter admission duration, and lower incidence of pneumonia.

Conclusion

This study found no statistical difference between influenza A and B, in symptoms, progression, and laboratory test, but those who were treated with oseltamivir given within 2 days of the onset of fever experienced more positive outcomes.

Keywords: Influenza, Seasonal Influenza A, Seasonal Influenza B

Figures and Tables

Fig. 1

The number of children according to the age group.

Fig. 2

Monthly distribution of the Influenza A & B.

Table 1

Baseline Characteristics in Influenza A & B

Data are median (range) or No. (%) of cases. Abbreviation: SD, standard deviation.

Table 2

Percentage of Symptoms and Signs in Influenza A & B

Data are No. (%) of cases.

Table 3

Laboratory Finding in Influenza A & B Patients Groups

Data are median (range).

Abbreviations: WBC, white blood cell; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.

Table 4

Comparison of Clinical Characteristics between Groups of Admission Patients with and without Complications

Data are median (range) or No. (%) of cases. Abbreviation: SD, standard deviation.

Table 5

Comparison of Progress among Three Groups in Accordance to Oseltamivir Use

Data are median (range) or No. (%) of cases.

Abbreviations: SD, standard deviation.

^*Mean admission duration was calculated from admitted patient only. ^†P<0.05 compared with no treatment group; χ²-test.

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