An Outbreak of Mumps in a High School, Seoul, 2013

Ha Ra Kang; Sung Yoon Kim; Hyo Hyun Cha; Young Min An; In Ah Park; Hae Ji Kang; Byung Wook Eun

doi:10.14776/piv.2015.22.1.1

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Kang, Kim, Cha, An, Park, Kang, and Eun: An Outbreak of Mumps in a High School, Seoul, 2013

Original Article

Pediatr Infect Vaccine 2015;22(1):1-6.

Published online: 21 January 2015

DOI: https://doi.org/10.14776/piv.2015.22.1.1

An Outbreak of Mumps in a High School, Seoul, 2013

Ha Ra Kang, M.D.^∗, Sung Yoon Kim, M.D.^∗, Hyo Hyun Cha, M.D.^∗, Young Min An, MD. Ph.D.^∗,^†, In Ah Park^‡, Hae Ji Kang, Ph.D.^§, Byung Wook Eun, M.D. Ph.D.^∗,^†

^∗Department of Pediatrics, Eulji General Hospital, Seoul, Republic of Korea

^† Department of Pediatrics, Eulji University School of Medicine, Daejeon, Republic of Korea

^‡Nowon —Gu Health Care Center‘, Seoul, Republic of Korea

^§Division of Respiratory Viruses, Korea National Institute of Health’, Centers for Disease Control & Prevention, Chungcheongbuk—do, Republic of Korea

Received 13 August 20141 October 2014 Accepted 6 October 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study investigated an outbreak of mumps affecting students in a high school (S high school) in Seoul, with an evaluation of the diagnostic utility of the mumps polymerase chain reaction (PCR) assay.

Methods

S high school students that presented to health care providers with mumps symptoms between April 2013 and July 2013 were surveyed for the monthly distribution of symptom onset and their grade level. Mumps PCR assays were performed using buccal swabs from some of these students.

Results

During the survey period, 77 students presented with suspected cases of mumps. The monthly distribution of symptom onset was as follows: one in April, 17 in May, 54 in June, and five in July. With regard to grade level, 26 students were in their first year, 28 were in their second year, and 23 were in their third year. Of the 18 students tested with PCR assays, five had positive results. Samples were collected within 3 days of symptom onset in 15 of the 18 students, and positive PCR results were obtained in five of these 15 students. The PCR results of the remaining three students from whom samples were collected more than 3 days after the onset of symptoms were negative (P2024).

Conclusions

We evaluated the epidemiological aspects of an outbreak of mumps in a high school. Mumps PCR might be epidemiologically useful if performed within 3 days of the onset of symptoms in suspected cases.

Keywords: Mumps, Outbreaks, Adolescent, Polymerase Chain Reaction

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Fig. 1.

Monthly and per school year distribution of mumps notified cases in 5 high school.

Fig. 2.

Age distribution of mumps notified cases at Eulji General Hospital. ∗Ten out of 29 male cases were the students of S high school.

Table 1.

Mumps PCR and Igm Results in Mumps Cases of High School

	Positive/No. of tested student	Negative/No. of tested student	Pvalue
Mumps PCR bv buccal swab
Onset of symptom within 3 days	5/15 (33.3%)	10/15	0.24
Onset of symptom after 3 davs	0/3 (0%)	3/3
Mumps IgM	2/5 (40%)	3/5

Abbreviation: PCR, polymerase chain reaction.

Table 2.

Laboratory Test Results of Patients Notified as Mumps who Visited Eulji General Hospital from April 2013 to July 2013 (N=39)

Laboratory test (N0. of patients)	S high school (N=10)/N0. of tested patients	Others∗ (N=29)/No. of tested patients	Pvalue I
Mumps PCR bv buccal swab
Tested (12)
Positive (1)	0/5 (0%)	1/7 (14%)	0.38
Negative (11)	5/5 (100%)	6/7 (86%)
Not tested (27)	5	22
Mumps IqM
Tested (24)
Positive (4)	2/5 (40%)	2/19(11%)	0.12
Neqative (20)	3/5 (60%)	17/19 (89%)
Not tested (15)	5	10
Mumps IgG
Tested (3)
>F0urfold rise (1)	1/2 (50%)	0/ 1 (0%)	0.39
<Fourf0\|d rise (2)	1/2 (50%)	1/1 (100%)
Not tested (36)	8	28
Amvlase
Tested (24)
>160 U/L(18)	4/5 (80%)	14/19 (74%)	0.78
<160 U/L (6)	1/5 (20%)	5/19 (26%)
Not tested (15)	5	10

^∗ Patients except 5 high school students. Abbreviation: PCR, polymerase chain reaction.

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