Journal List > Pediatr Infect Vaccine > v.23(2) > 1095940

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Cha, Kim, Lee, Cho, Ahn, and Kim: Vaccine Evaluation Studies Performed in Korea from 2000 to 2014
Original Article

Pediatric Infection & Vaccine 2016; 23(2): 117-127.

Published online: 25 August 2016

DOI: https://doi.org/10.14776/piv.2016.23.2.117

Vaccine Evaluation Studies Performed in Korea from 2000 to 2014

Jihei Cha1, Han Wool Kim2, Soyoung Lee1, 2, Hye Kyung Cho3, Jong Gyun Ahn1, Kyung-Hyo Kim1, 2

1Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.

2Center for Vaccine Evaluation and Study, Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.

3Department of Pediatrics, School of Medicine, Gachon University, Incheon, Korea.

Corresponding author (kaykim@ewha.ac.kr)

Received 29 December 2015       Revised 25 February 2016       Accepted 9 March 2016

Copyright © 2016 The Korean Society of Pediatric Infectious Diseases

Abstract

Purpose

Vaccine evaluation studies were initiated from 2000 by the Ministry of Food and Drug Safety to produce proper data about the safety and immunogenicity of vaccines. The purpose of this study was to review studies and reports on evaluation of vaccine such as immunogenicity, efficacy, effectiveness, safety and other related topics in order to find and analyze the data on the usefulness of each vaccine.

Methods

From 2000 to 2014, the project "The vaccine evaluation" had been performed by several researchers, and studies and reports of vaccine evaluation. We reviewed the results and outcomes of studies regarding the evaluation of vaccine's usefulness and analyzed the possibilities of applying these data for establishing vaccine policies. For each vaccine, data analysis and organization were done according to evaluation fields.

Results

A total of 83 studies were performed on vaccines from 2000 to 2014. For each vaccine, 8 studies were performed on BCG, 14 on DTaP/Td, 1 on poliovirus, 5 on Hib, 3 on pneumococcus, 11 on influenza, 3 on hepatitis A, 11 on MMR, 11 on varicella, and 16 on Japanese encephalitis. All studies were analyzed by the following evaluation area, such as safety, immunogenicity, seroprevalence, persistence of immunity, efficacy, effectiveness, vaccine evaluation methods, quality control product for vaccine, and others.

Conclusions

Vaccine evaluation studies performed in Korea may be useful as references for establishing vaccination strategy and policy and could be used as baseline data for future studies on vaccine evaluation, vaccine policy establishment, and public/expert vaccine education in Korea.

Keywords: Vaccines, Evaluation studies, Republic of Korea

Figures and Tables

Fig. 1

Numbers and percentage of vaccines performed in vaccine evaluation studies in 2000–2014 (Total number of studies=83).

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Fig. 2

Numbers and percentage of evaluation areas performed in vaccine evaluation studies in 2000–2014 (Total number of evaluation areas=133).

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Table 1

Vaccine Evaluation Studies Performed in 2000–2014 According to Vaccines and Evaluation Areas

piv-23-117-i001

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