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Abstract
Purpose
The objective of this study was to compare the clinical characteristics of influenza A and B infections and analyze the effect of oseltamivir in hospitalized children.
Methods
We investigated children under the age of 15, who were diagnosed with influenza A/H1N1, A/H3N2, or B from January to April 2014. The subjects were admitted to the Changwon Fatima Hospital and diagnosed using a rapid antigen test from nasopharyngeal swabs. The medical records of the patients were retrospectively reviewed.
Results
A total of 302 pediatric patients with influenza were enrolled. Influenza B infection was the most common type (n=187, 61.9%), followed by A/H3N2 (n=100, 33.1%) and A/H1N1 (n=15, 5.0%). Compared to patients diagnosed with influenza A, patients diagnosed with influenza B were older (P=0.005), and the duration of fever was significantly longer (P=0.001). A total of 161 patients (53.3%) had been vaccinated against influenza during the season, before admission. Among the patients infected with A/H3N2 and B, the duration of fever was shorter in oseltamivir recipients compared to oseltamivir non-recipients (P=0.026 and P=0.004, respectively).
Conclusions
There were significant differences between influenza A and B groups in terms of age, demographics, and clinical course. Although the effectiveness of oseltamivir on influenza differs according to the type of influenza, our data provides evidence that oseltamivir is beneficial for both A and B infections.
Figures and Tables
Fig. 2
The number of children with or without familial contacts in (A) children under 24 months, and in (B) 24 months to 6 years old according to the type of influenza.
Table 1
Clinical and Laboratory Characteristics according to Type of Influenza
Values are presented as mean±standard deviation or number (%).
*The sample population for the duration of fever after oseltamirvir administration (day) are 14, 70, and 130 for A/H1N1, A/H3N2, and B, respectively.
†The sample population for the duration of fever in non-oseltamirvir recepients (day) are 30 and 57 for A/H3N2 and B, respectively.
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