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Abstract
Purpose
Coronary arterial lesions (CALs) were reported to have developed in children with systemic inflammatory diseases, as well as those with Kawasaki disease (KD). The purpose of this study was to confirm that the CAL development in children with KD occurs in a mouse model of sepsis presenting typical systemic inflammatory response syndrome (SIRS).
Methods
To induce the sepsis mouse model with SIRS, 6-week-old C57BL/6 mice were intraperitoneally injected with endotoxin. We compared histological findings of the major organs between the control and the sepsis groups and examined CAL in the heart of the septic mice.
Results
Infiltrating inflammatory cells were relatively increased in the heart, liver, and kidneys of the sepsis group, compared with those of the control group. We confirmed lymphocytic infiltration in the myocardium (myocarditis) and the pericardial soft tissue of the heart. Furthermore, coronary artery of the septic mouse was identified, but CAL was not observed.
Conclusions
In this study, we failed to confirm the existence of CAL in a mouse model of sepsis. However, it is well-known that CALs are seen in many kinds of diseases that cause SIRS. Our findings suggest further investigation into the clinical significance of CAL in various systemic inflammatory diseases, including KD.
Figures and Tables
Fig. 1
Histologic findings (H&E stain) of the major organs are compared between the control and the sepsis groups. (A) Heart, control: unremarkable (×100). (B) Heart, sepsis: lymphocytic infiltration in the myocardium and the pericardial soft tissue (×40; inset, ×200). (C) Liver, control: unremarkable (×100). (D) Liver, sepsis: a few microabscesses (×100; inset, ×200). (E) Kidney, control: unremarkable (×100). (F) Kidney, sepsis: lymphocytic infiltration in the perirenal soft tissue (×100).
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