Abstract
Background
Objective
Methods
Results
Figures and Tables
Fig. 1
Flow chart of patients with congenital melanocytic nevi (CMN) treated with intense pulsed light (IPL) alone and in combination with erbium: yttrium-aluminum-garnet (Er: YAG) laser. FU: follow-up.
![ad-29-39-g001](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g001.jpg)
Fig. 2
(A) Photo before treatment. (B) Treatment outcome measured at treatment completion is clear in patient 3.
![ad-29-39-g002](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g002.jpg)
Fig. 3
(A) Photo before treatment. (B) The outcome at treatment completion is clear in patient 26, (C) but she later on shows recurrence at follow-up evaluation, which is made 14 months after treatment completion.
![ad-29-39-g003](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g003.jpg)
Fig. 4
Epidermal detachment and profound collagen degeneration in the superficial and mid dermis are the findings of a biopsy specimen from patient 1 taken immediately after intense pulsed light treatment (×50; A: H&E, B: periodic acid-Schiff [PAS]).
![ad-29-39-g004](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g004.jpg)
Fig. 5
(A) Photo before treatment. (B) Patient 10 experiences bullae following intense pulsed light therapy. (C) congenital melanocytic nevi is cleared at the time of treatment completion with mild scarring and erythema. (D) Follow-up 29 months after treatment completion.
![ad-29-39-g005](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g005.jpg)
Fig. 6
(A) Photo before treatment. (B) Patient 15, who receives 23 sessions of intense pulsed light (IPL) and 5 sessions of erbium: yttrium-aluminum-garnet/IPL combination therapy achieves improvement of congenital melanocytic nevi but is not able to complete treatment due to change of residence. (C) Follow-up (FU) photo sent from her mother, 5 months after the last treatment shows significant re-pigmentation. (D) Photo FU after the first staged excision.
![ad-29-39-g006](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g006.jpg)
Fig. 7
(A) The clinical photo (patient 11) and (B, C) histology before the start of treatment (×50; B: H&E, C: periodic acid-Schiff [PAS]). (D) A clinical photo after treatment completion (the focal scarring seen here is due to repeated punch biopsy). (E, F) The follow-up skin biopsy shows remnant nevus cells in the deep dermis (×50; E: H&E, F: PAS).
![ad-29-39-g007](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-g007.jpg)
Table 1
Overview of CMN patients who received IPL treatment (IPL alone or in combination with Er: YAG laser)
![ad-29-39-i001](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-i001.jpg)
Treatment outcome 5-point scale: 1=poor (no change, with lightening of 15% or less); 2=fair (slight improvement, with lightening of 16%~50%); 3=good (improvement, with lightening of 51%~75%); 4=excellent (lightening of 76%~95%); and 5=clear (near-complete disappearance of the lesion, with lightening of 95% or more).
CMN: congenital melanocytic nevi, IPL: intense pulsed light, Er: YAG: erbium: yttrium-aluminum-garnet, Tx: treatment, FU: follow-up, F: female, M: male.
Table 2
Number of IPL treatment alone and the number of Er: YAG/IPL combined between the small and medium sized CMN
![ad-29-39-i002](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-i002.jpg)
Table 3
Initial treatment outcome and the follow-up outcome between the small CMN and the medium sized CMN
![ad-29-39-i003](/upload/SynapseData/ArticleImage/0140ad/ad-29-39-i003.jpg)
Small CMN (n=7) | Medium sized CMN (n=10) | Paired t-test | |
---|---|---|---|
Initial outcome at treatment completion | 4.6±0.5 | 4.1±0.3 | p=0.037 |
FU outcome | 3.7±1.1 | 2.7±0.7 | p=0.033 |
Values are presented as mean±standard deviation. Treatment outcome 5-point scale: 1=poor (no change, with lightening of 15% or less); 2=fair (slight improvement, with lightening of 16%~50%); 3=good (improvement, with lightening of 51%~75%); 4=excellent (lightening of 76%~95%); and 5=clear (near-complete disappearance of the lesion, with lightening of 95% or more).
CMN: congenital melanocytic nevi, FU: follow-up.
ACKNOWLEDGMENT
References
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