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Allergy Asthma Respir Dis. 2018 Jan;6(1):68-71. Korean.
Published online Jan 31, 2018.
© 2018 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Successful desensitization to fluconazole induced delayed hypersensitivity: A case report
Yeon-Jeong Heo,1 Seung-Woo Park,1 Kyu-Sun Lee,1 Hye-Ryun Kang,2 and Jae-Woo Kwon1,3
1Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
2Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
3Department of Allergy and Clinical Immunology, Kangwon National University Hospital, Chuncheon, Korea.

Correspondence to: Jae-Woo Kwon. Department of Internal Medicine, Kangwon National University Hospital, 156 Baengnyeong-ro, Chuncheon 24289, Korea. Tel: +82-33-258-9370, Fax: +82-33-258-2404, Email:
Received April 15, 2017; Revised August 02, 2017; Accepted September 08, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (


Fluconazole is a triazole-based first-generation antifungal agent and has excellent effects on candidiasis and cryptococcosis. Hypersensitivity has been reported as a side effect of fluconazole. A 76-year-old female patient used fluconazole for consolidation therapy for cryptococcal meningitis, but showed delayed hypersensitivity with skin rashes and itching sensation of the whole body. For desensitization, was attempted by administering 12-step, 1:1 fluconazole solutions were administered intravenously at sequentially increasing infusion rates. After successful quick desensitization to fluconazole, fluconazole was continuously used as a consolidation therapy for cryptococcal meningitis. We herein report a case of delayed hypersensitivity reaction to fluconazole in consolidation therpy with cryptococcal meningitis who successfully completed desensitization.

Keywords: Desensitization; Fluconazole


Fig. 1
Clinical features of the fluconazole-induced delayed type hypersensitivity. There was diffuse patch eruption involving the trunk (A) and extremities (B) with itching and blanching, which continued for several days.
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Table 1
The preparation of 1-bottle solution used in the rapid desensitization protocol
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Table 2
Desensitization protocol used in the current case of the fluconazole-induced delayed hypersensitivity
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