Journal List > Allergy Asthma Respir Dis > v.6(1) > 1095715

Allergy Asthma Respir Dis. 2018 Jan;6(1):47-53. Korean.
Published online Jan 31, 2018.  https://doi.org/10.4168/aard.2018.6.1.47
© 2018 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Bronchiolitis severity according to the infected viruses
Su Jin Lee, Sang Kyu Park, Ji Hyun Kim, and Sung Min Cho
Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.

Correspondence to: Ji Hyun Kim. Department of Pediatrics, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang 10326, Korea. Tel: +82-31-961-7190, Fax: +82-31-961-7188, Email: eogurdl@gmail.com
Received March 10, 2017; Revised October 24, 2017; Accepted October 24, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).


Abstract

Purpose

The aim of this study was to evaluate the severity of disease in children with acute bronchiolitis according to the type of infected virus.

Methods

From November 2007 to May 2015, 768 patients under 2 years of age who underwent real time-polymerase chain reaction of nasopharyngeal aspirates admitted to the Department of Pediatrics of Dongguk University Ilsan Hospital for acute bronchiolitis were enrolled. Severe bronchiolitis was defined as presence of one or more kinds among tachypnea, chest retraction, needs of O2 inhalation or ventilator care.

Results

The severity of bronchiolitis was increased with shorter fever duration (P<0.001) and previous wheezing episodes (P=0.005). In the case of single infection, respiratory syncytial virus (RSV) A only increased the severity of acute bronchiolitis (P=0.012). However, the severity of illness decreased when RSV A coinfected with adenovirus (P=0.034), human rhinovirus (P=0.038), or human coronavirus NL63 (P=0.042). On the other hand, when human rhinovirus was coinfected with enterovirus (P=0.013) or parainfluenza 3 (P=0.019), the severity was increased. When human metapneumovirus coinfected with human bocavirus, the severity was increased (P=0.038).

Conclusion

Acute bronchiolitis was associated with increased severity only when RSV A infected solely, but several viruses increased or decreased the severity when coinfection occurred. Therefore, it may be helpful in predicting the course of the acute bronchiolitis according to the affected virus.

Keywords: Bronchiolitis; Infant; Respiratory syncytial virus; Severity

Figures


Fig. 1
Year-round change of acute bronchiolitis with 16 respiratory viruses isolated for 768 hospitalized children.
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Tables


Table 1
Clinical characteristics of hospitalized children with acute bronchiolitis
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Table 2
Clinical characteristics of hospitalized children with acute bronchiolitis analyzed according to disease severity
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Table 3
The ratio of single infection to coinfection of respiratory viruses isolated for 768 hospitalized children with acute bronchiolitis
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Table 4
Correlation of severity with coinfected viruses for 768 hospitalized children with acute bronchiolitis*
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