Effect of Remote Ischemic Preconditioning on Maximal Exercise Tolerance in Young Adults

Eun Sun Yoon; Sae Young Jae

doi:10.5763/kjsm.2018.36.2.77

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Yoon and Jae: Effect of Remote Ischemic Preconditioning on Maximal Exercise Tolerance in Young Adults

Clinical Article

Sports Science

The Korean Journal of Sports Medicine 2018; 36(2): 77-83.

Published online: 8 June 2018

DOI: https://doi.org/10.5763/kjsm.2018.36.2.77

Effect of Remote Ischemic Preconditioning on Maximal Exercise Tolerance in Young Adults

Eun Sun Yoon, Sae Young Jae

Department of Sport Science, University of Seoul, Seoul, Korea.

Correspondence: Sae Young Jae. Department of Sport Science, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul 02504, Korea. Tel: +82-2-6490-2953, Fax: +82-2-6490-2949, syjae@uos.ac.kr

Received 16 April 2018 Revised 25 May 2018 Accepted 28 May 2018

The Korean Society of Sports Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Remote ischemic preconditioning (RIPC), induced by repeated bouts of ischemia followed by reperfusion of the arm or leg is a noninvasive strategy to protect a target organ against oxidative stress and injury caused by ischemia and reperfusion. Interestingly, recent evidence suggests that RIPC may also improve exercise performance by increasing maximal oxygen consumption, but such finding remain equivocal. As such, the purpose of the study was to examine the effect of RIPC on exercise performance in healthy individuals.

Methods

In a randomized cross-over design, 17 healthy male participants (age, 23±3 years) were exposed to either a sham control (six cycles of 5 minutes bilateral thigh cuff occlusion at 20 mm Hg) or RIPC (six cycles of 5 minutes bilateral thigh cuff occlusion at 180 mm Hg) an hour before a maximal exercise test. We measured maximal oxygen consumption, power output, heat rate, blood pressure, and blood lactate as exercise performance parameters during a maximal exercise test performed on an upright bicycle.

Results

Compared with the sham control, RIPC improved maximal oxygen consumption (7.4%, p=0.025) and maximal power output (11.5%, p=0.010), whereas other exercise performance parameters remained unchanged with RIPC (p>0.05).

Conclusion

Taken together, the improvements in maximal oxygen consumption and maximal power output induced by RIPC may suggest that RIPC should be considered as a method for improving exercise performance.

Keywords: Blood circulation, Exercise tolerance, Ischemic preconditioning, Oxygen consumption

Figures and Tables

Fig. 1

Experimental design. RIPC: remote ischemic preconditioning, CON: control, RL: right leg, LL: left leg, HR: heart rate.

Fig. 2

Mean and individual maximal oxygen consumption during the maximal exercise test without and with ischemic preconditioning. Control, 36.45±4.06 mL/kg/min; RIPC, 39.20±5.06 mL/kg/min. RIPC: remote ischemic preconditioning.

Table 1

Physical characteristics of the subjects (n=17)

SD: standard deviation.

Table 2

Effect of RIPC on the parameters of maximal exercise performance during and recovery after exercise test

Values are presented as mean±standard deviation.

RIPC: remote ischemic preconditioning, HR: heart rate, SBP: systolic blood pressure, DBP: diastolic blood pressure, RPE: rating of perceived exertion.

By two-way repeated analysis of variance for RPE and lactate changes: ^*Time, <0.001; trial, 0.319; interaction, 0.052; ^†Time, <0.001; trial, 0.501; interaction, 0.854.

Notes

This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea in 2015 (NRF-2015 S1A5B5A07044395).

^{Conflict of Interest} No potential conflict of interest relevant to this article was reported.

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