Abstract
Purpose
This study aimed to analyze the prevalence of allergic diseases in Korean schoolchildren according to their residential areas in 2010.
Methods
A nationwide, cross-sectional study was conducted in children aged 6–7 years (n=4,003) and adolescents aged 12–13 years (n=4,112) who were randomly selected. Demographic and disease-related information was obtained through a Korean version of ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire, and skin prick tests for 18 inhalant allergens were performed.
Results
There was statistically significant regional difference in the prevalence of allergic rhinitis (AR) (P<0.05). The regions with highest and lowest prevalence in 12- to 13-year-old children were as follows: Chungcheong and Honam in “Diagnosis of AR, ever”(33.7% vs. 24.5%), Jeju and Yeongnam in “Treatment of AR, last 12 months” (25.5% vs. 18.0%), Chungcheong and Yeongnam in “Rhinitis with sensitization” (31.6% vs. 23.6%). The regions with highest and lowest prevalence in 6–7 years old children were as follows: Yeongnam and Seoul in “Diagnosis of AR, ever” (42.1% vs. 31.0%), Yeongnam and Jeju in “Treatment of AR, last 12 months” (31.8% vs. 21.9%), Jeju and Seoul in “Rhinitis with sensitization” (26.0% vs. 18.4%). We also found a regional difference in inhalant allergens among the children with “rhinitis with sensitization”.
References
1. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006; 368:733–43.
2. Oh JW, Kim KE, Pyun BY, Lee HR, Choung JT, Hong SJ, et al. Nationwide study for epidemiological change of atopic dermatitis in school aged children between 1995 and 2000 and kindergarten aged children in 2003 in Korea. Pediatr Allergy Respir Dis. 2003; 13:227–37.
3. Lee SI. Prevalence of childhood asthma in Korea: international study of asthma and allergies in childhood. Allergy Asthma Immunol Res. 2010; 2:61–4.
4. Hong SJ, Ahn KM, Lee SY, Kim KE. The prevalences of asthma and allergic diseases in Korean children. Korean J Pediatr. 2008; 51:343–50.
5. Son KY, Park KS, Hwang HH, Yun BS, Lee SJ, Kim MA, et al. Prevalence of allergic diseases among primary school children in Ilsan, Gyeonggi and Changes of symptoms after environmental control in 2005. Pediatr Allergy Respir Dis. 2007; 17:384–93.
6. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, et al. Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey. J Korean Med Sci. 2001; 16:155–64.
7. Hong SJ, Kim SW, Oh JW, Rah YH, Ahn YM, Kim KE, et al. The validity of the ISAAC written questionnaire and the ISAAC video questionnaire (AVQ 3.0) for predicting asthma associated with bronchial hyperreactivity in a group of 13–14 year old Korean schoolchildren. J Korean Med Sci. 2003; 18:48–52.
8. Hong SJ, Lee MS, Sohn MH, Shim JY, Han YS, Park KS, et al. Self-reported prevalence and risk factors of asthma among Korean adolescents: 5-year follow-up study, 1995–2000. Clin Exp Allergy. 2004; 34:1556–62.
9. Hong SJ, Lee MS, Lee SY, Ahn KM, Oh JW, Kim KE, et al. High body mass index and dietary pattern are associated with childhood asthma. Pediatr Pulmonol. 2006; 41:1118–24.
10. Lee SY, Hong SJ, Kim BS, Kim CK, Lee DJ, Lee DK, et al. The association between recent dietary pattern as a risk factor of 12-month asthma symptom prevalence in Korean elementary school children. Pediatr Allergy Respir Dis. 2006; 16:296–305.
11. Ahn KM, Lee MS, Hong SJ, Lim DH, Ahn YM, Lee HR, et al. Fever, use of antibiotics, and acute gastroenteritis during infancy as risk factors for the development of asthma in Korean school-age children. J Asthma. 2005; 42:745–50.
12. Seong HU, Cho SD, Park SY, Yang JM, Lim DH, Kim JH, et al. Nation-wide survey on the prevalence of allergic diseases according to region and age. Pediatr Allergy Respir Dis. 2012; 22:224–31.
13. Lee KJ, Kwon HJ, Ahn K, Chae Y, Hahm MI, Kim JH, et al. Sampling design and design effect analysis for the epidemiologic study of allergic diseases in Korean children. Surv Res. 2012; 13:111–28.
14. Ahn K, Kim J, Kwon HJ, Chae Y, Hahm MI, Lee KJ, et al. The prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in Korean children: nationwide cross-sectional survey using complex sampling design. J Korean Med Assoc. 2011; 54:769–78.
15. Oh JW. Characteristics and distribution of airborne pollen and mold. Pediatr Allergy Respir Dis. 1998; 8:1–15.
16. Oh JW. Development of pollen concentration prediction models. J Korean Med Assoc. 2009; 52:579–91.
17. Kim J, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, et al. Sensitization to aeroallergens in Korean children: a population-based study in 2010. J Korean Med Sci. 2011; 26:1165–72.
18. Bibi H, Shoseyov D, Feigenbaum D, Nir P, Shiachi R, Scharff S, et al. Comparison of positive allergy skin tests among asthmatic children from rural and urban areas living within small geographic area. Ann Allergy Asthma Immunol. 2002; 88:416–20.
19. Wong GW, Chow CM. Childhood asthma epidemiology: insights from comparative studies of rural and urban populations. Pediatr Pulmonol. 2008; 43:107–16.
20. Sozańska B, Blaszczyk M, Pearce N, Cullinan P. Atopy and allergic respiratory disease in rural Poland before and after accession to the European Union. J Allergy Clin Immunol. 2014; 133:1347–53.
21. Lee SY, Kwon JW, Seo JH, Song YH, Kim BJ, Yu J, et al. Prevalence of atopy and allergic diseases in Korean children: associations with a farming environment and rural lifestyle. Int Arch Allergy Immunol. 2012; 158:168–74.
22. Hong S, Son DK, Lim WR, Kim SH, Kim H, Yum HY, et al. The prevalence of atopic dermatitis, asthma, and allergic rhinitis and the comorbidity of allergic diseases in children. Environ Health Toxicol. 2012; 27:e2012006.