Abstract
Background
Methods
Results
Acknowledgments
References
Table 1
Most of the continuous variables did not show normal distributions except FX, AT and MA; therefore, continuous variables are presented as median (range) and number (percentage) for continuous and categorical variables, respectively.
*P<0.05; †P<0.005; P values were obtained from the comparison of patients with WHO bleeding grade of 1 or ≥2 with those with WHO bleeding grade of 0 by using Mann-Whitney U and χ2 test for quantitative and categorical variables, respectively, with Bonferroni correction for multiple testing; ‡P value: Kruskal-Wallis analysis for continuous variables; §Thrombocytopenia included immune thrombocytopenia (n=35) and thrombocytopenia due to peripheral consumption (n=27); ‖Hematologic malignancies included MDS (n=16), AML (n=16), ALL (n=4), and multiple myeloma (n=8).
Abbreviations: aPTT, activated partial thromboplastin time; AT, antithrombin; CI, coagulation index; ETP, endogenous thrombin potential; F, factor; MA, maximum amplitude; LY, lysis; PT, prothrombin time; WBC, white blood cell.
Table 2
Data are presented as standardized regression coefficients (β).
*P<0.05; †P<0.01.
Abbreviations: AT, antithrombin; CI, coagulation index; ETP, endogenous thrombin potential; F, factor; K, coagulation time; Ly, lysis; MA, maximum amplitude; NA, not accessible; PC, protein C; PS, protein S; R, reaction time.
Table 3
*Most of the continuous variables did not show normal distributions except MA, therefore, variables are presented as median (range); †P value: Mann-Whitney U test for results obtained from patients with WHO bleeding grade ≥2 or those with WHO bleeding grade of 0 or 1; ‡Platelet count was adjusted.
Abbreviations: CI, confidence interval; ETP, endogenous thrombin potential; MA, maximum amplitude; K, coagulation time; PT, prothrombin time.
Table 4
The cutoff values referred to the values producing the best diagnostic accuracy.
*Sensitivity and specificity are presented with 95% confidence intervals within the parenthesis.
Abbreviations: AUC, area under the concentration curve; ETP, endogenous thrombin potential; K, coagulation time; MA, maximum amplitude; NPV, negative predictive value; PPV, positive predictive value; PT, prothrombin time.