Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

Jung-Hyun Lee; Juhea Chang; Ho-Hyun Son

doi:10.5395/rde.2012.37.1.2

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Lee, Chang, and Son: Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

Review Article

Restorative Dentistry & Endodontics

Restorative Dentistry & Endodontics 2012; 37(1): 2-8.

Published online: 2 March 2012

DOI: https://doi.org/10.5395/rde.2012.37.1.2

Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

Jung-Hyun Lee, DDS¹, Juhea Chang, DDS, PhD², Ho-Hyun Son, DDS, PhD¹

PhD student

Resident

Professor

¹Department of Conservative Dentistry, Seoul National University School of Dentistry, Seoul, Korea.

²Clinic for Persons with Disabilities, Seoul National University Dental Hospital, Seoul, Korea.

Correspondence to Ho-Hyun Son, DDS, PhD. Professor, Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, 101 Daehag-ro, Jongro-gu, Seoul, Korea 110-749. TEL, +82-2-2072-2652; Fax, +82-2-2072-3859; hhson@snu.ac.kr

Received 6 September 2011 Revised 18 November 2011 Accepted 18 November 2011

©Copyights 2012. The Korean Academy of Conservative Dentistry.

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Keywords: Biomimetic remineralization, Chlorhexidine, Cross-linking agent, Dentin bonding, Ethanol wet-bonding, Matrix metalloproteinase

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