Relationship between Triglyceride and Bone Mineral Density in Healthy Korean Men

Jun-Seok Son; Hyun-Min Koh; Jong-kyung Park

doi:10.15384/kjhp.2015.15.3.115

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Son, Koh, and Park: Relationship between Triglyceride and Bone Mineral Density in Healthy Korean Men

Original Article

Korean J Health Promot 2015;15(3):115-120.

Published online: 19 December 2015

DOI: https://doi.org/10.15384/kjhp.2015.15.3.115

Relationship between Triglyceride and Bone Mineral Density in Healthy Korean Men

Jun-Seok Son¹, Hyun-Min Koh², Jong-kyung Park²

²Departments of Occupational & Environmental Medicine and Sungkyunkwan University School of Medicine, Changwon, Korea

²Family Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea

Corresponding author：Hyun-Min Koh, MD Department of Family Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 158 Paryong-ro, MasanHoewon-gu, Changwon 51353, Korea Tel: +82-55-290-6554, Fax: +82-55-290-1224 E-mail: sunkhm@naver.com

Received 29 April 2015 Accepted 13 August 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

As the elderly population increasing, the interest in osteoporosis, hyperlipidemia, and cardiovascular diseases has increased in recent years. In accordance with such trend, many studies regarding correlations between bone density and hyperlipidemia have been conducted. However, the study outcomes have been inconsistent so far, and most of the studies focused on females. Therefore, this study aimed to investigate the correlation between serum lipid levels and bone density in healthy Korean male adults.

Methods

This study surveyed 851 male adults, who visited an examination center at a university hospital, on smoking, drinking, hypertension, and diabetes history. A laboratory examination measured total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apolipoprotein A-1, and apolipoprotein B. For bone density, lumbar, femoral neck, and femur were measured using dual energy X-ray absorptiometry.

Results

Body mass index (BMI) and bone density T-value showed a positive correlation. Triglyceride exhibited a positive correlation with bone density T-value, and they still revealed a significant positive correlation after correcting for age and BMI. While high density lipoprotein cholesterol showed a negative correlation with bone density, they were not correlated significantly after correcting for age and BMI. There was no correlation found between low density lipoprotein cholesterol and bone density.

Conclusions

This study confirmed that bone densities of all areas measured were significantly increased in Korean male adults as triglyceride increased. Total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol did not show a significant correlation with bone density.

Keywords: Bone density, Dyslipidemias, Triglycerides, Male

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Table 1.

General characteristics of the study subjects^a

Characteristics	Total (n=851)
Age, y	47.81±6.13
BMI, kg/m²	23.89±2.66
TC, mg/dL	199.89±33.90
HDL-C, mg/dL	55.88±13.49
LDL-C, mg/dL	130.22±31.95
Triglyceride, mg/dL	125.87±77.55
Apo A-1, mg/dL	141.80±23.72
Apo B, mg/dL	99.81±23.82
Lumbar BMD T-score	-0.86±1.10
Femur neck BMD T-score	-0.17±0.99
Total hip BMD T-score	0.19±0.94
Current smoker, %	342 (40.2)
Alcohol consumption, %	824 (96.8)

Abbreviations: BMI, body mass index; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; BMD, bone mineral density.

^a Values are presented as N (%) or mean±SD.

Table 2.

Pearson’s correlation coefficients between BMD T-score and other characteristics

	Lumbar		Femur neck		Total hip
	r^a	P^b	r^a	P^b	r^a	P^b
Age, y	-0.101	0.018	-0.172	<0.001	-0.091	0.024
BMI, kg/m²	0.234	<0.001	0.342	<0.001	0.369	<0.001
TC, mg/dL	-0.023	0.504	-0.012	0.732	0.004	0.910
HDL-C, mg/dL	-0.068	0.047	-0.131	<0.001	-0.127	<0.001
LDL-C, mg/dL	0.010	0.770	0.016	0.633	0.019	0.547
Triglyceride, mg/dL	0.068	0.047	0.077	0.024	0.089	0.009
Apo A-1, mg/dL	-0.067	0.048	-0.104	0.002	-0.083	0.016
Apo B, mg/dL	0.010	0.773	0.037	0.284	0.050	0.142

Abbreviations: BMI, body mass index; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; BMD, bone mineral density.

^a Pearson’s correlation coefficients.

^b Calculated by Pearson’s correlation analysis.

Table 3.

Age and BMI-adjusted partial correlation analysis between BMD T-score and serum lipids

	Lumbar		Femur neck		Total hip
	r^a	P^b	r^a	P^b	r^a	P^b
TC	-0.058	0.123	-0.071	0.056	-0.055	0.140
HDL-C	-0.079	0.064	-0.068	0.091	-0.059	0.124
LDL-C	0.021	0.571	0.034	0.363	0.027	0.472
Triglyceride	0.088	0.018	0.092	0.014	0.078	0.046
Apo A-1	-0.060	0.087	-0.045	0.225	-0.020	0.584
Apo B	0.058	0.122	0.062	0.097	0.046	0.219

Abbreviations: BMI, body mass index; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; BMD, bone mineral density.

^a Partial correlation coefficient adjusted for age and BMD.

^b Calculated by partial correlation analysis adjusted for age and BMI.

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