Association between Pulse Pressure and Carotid Intima-Media Thickness in Healthy Adolescents: Jangseong High School Study

Dong Phil Choi; Joo Young Lee; Vogue Ahn; Hyeon Chang Kim

doi:10.5646/jksh.2012.18.1.29

Journal List > J Korean Soc Hypertens > v.18(1) > 1089797

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Choi, Lee, Ahn, and Kim: Association between Pulse Pressure and Carotid Intima-Media Thickness in Healthy Adolescents: Jangseong High School Study

Original Article

Journal of the Korean Society of Hypertension

Journal of the Korean Society of Hypertension 2012; 18(1): 29-37.

Published online: 31 March 2012

DOI: https://doi.org/10.5646/jksh.2012.18.1.29

Association between Pulse Pressure and Carotid Intima-Media Thickness in Healthy Adolescents: Jangseong High School Study

Dong Phil Choi, MD, Joo Young Lee, MD, Vogue Ahn, MD, Hyeon Chang Kim, MD

Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: hckim@yuhs.ac

Received 27 January 2012 Revised 21 March 2012 Accepted 29 March 2012

Abstract

Background

Wide pulse pressure associates with atherosclerosis, but it is unclear whether pulse pressure within a relatively normal range is associated with atherosclerosis in younger populations. The aim of this study was to investigate the association between pulse pressure and the carotid intima-media thickness (IMT) in healthy adolescents.

Methods

Study participants included 250 (129 males and 121 females) adolescents who were 17 to 19 years old and in the third grade of a high school in Jangseong, Korea between November 20 and December 1, 2009. Pulse pressure was determined as the difference between systolic blood pressure and diastolic blood pressure which were measured with an oscillometric sphygmomanometer. IMT values were ultrasonographically measured at right and left common carotid arteries, and average of the mean IMT at each artery was used for analysis.

Results

There was a significant correlation between pulse pressure and carotid IMT before (Pearson coefficient r = 0.2037, p = 0.001) and after (r = 0.1479, p = 0.020) adjustment for sex. When adjusted for sex, age, waist circumference, fasting blood glucose, and total/high-density lipoprotein cholesterol ratio, 10 mm Hg increase in pulse pressure was associated with increase of IMT in total (β = 10.9 µm, p = 0.003), in males (β = 17.3 µm, p < 0.001), but not in females (β = 3.609 µm, p = 0.518).

Conclusions

This study suggests that higher pulse pressure may be associated with increased carotid IMT even in healthy male adolescents.

Keywords: Pulse pressure, Carotid intima-media thickness, Adolescent

Figures and Tables

Fig. 1

Carotid intima-media thickness (IMT) across pulse pressure quintiles. Columns indicate mean levels and lines indicate standard errors.

Table 1

Characteristics of study participants

Values are presented as mean ± standard deviation or number (%).

SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high density lipoprotein; IMT, intima-media thickness.

Table 2

Correlations between major cardiovascular risk factors and carotid IMT in 250 adolescents

IMT, intima-media thickness; HDL, high density lipoprotein.

Table 3

Relationships between pulse pressure and carotid IMT in 250 adolescents

IMT, intima-media thickness; SD, standard deviation; PP, pulse pressure.

^*Adjusted for sex when analyzed for total participants.

^†Adjusted for age, waist circumference, fasting plasma glucose, and total / high density lipoprotein cholesterol ratio.

Table 4

Association between pulse pressure and carotid intima-media thickness (IMT) among adolescents in the current study and previous studies

^*Adjusted for sex.

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