Journal List > Korean J Obstet Gynecol > v.55(12) > 1088569

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Lee, Lee, Park, Cha, Park, Kim, Yang, Song, Koong, Kang, and Kim: Serum anti-Müllerian hormone levels in the patients with ovarian endometriosis undergoing surgical treatment
Original Article
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(12): 935-939.

Published online: 18 December 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.12.935

Serum anti-Müllerian hormone levels in the patients with ovarian endometriosis undergoing surgical treatment

Jea Ra Lee, MD, Min-Young Lee, MD, Hye-Woen Park, MD, Sun Wha Cha, MD, Chan Woo Park, MD, Jin Yeong Kim, MD, Kwang Moon Yang, MD, In Ok Song, MD, Mi Kyoung Koong, MD, Inn Soo Kang, MD, Hye-Ok Kim, MD

Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.

Corresponding author: Hye Ok Kim, MD. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 100-380, Korea. Tel: +82-2-2000-4738, Fax: +82-2-2000-7790, ok58163@hanmail.net

Received 11 June 2012       Revised 11 October 2012       Accepted 14 October 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

To evaluate the difference of serumanti-Müllerian hormone (AMH) levels in women between undergoing previous ovarian surgery with endometriosis and controls.

Methods

We reviewed medical records and evaluated the serum AMH levels of 217 women (26-40 years old) between March 2010 and January 2011, retrospectively. One hundred five patients were previously undergone the ovarian surgery of endometriosis (study group) and 112 women has never undergone ovarian surgery as controls (control group). Exclusion criteria was following factors: irregular menstruation, polycystic ovary syndrome, high BMI (≥30 kg/m2), other endocrine disease.

Results

The mean age in study group was not different with control group (32.5 ± 3.6 vs. 33.0 ± 3.8 year). The mean serum AMH levels significantly lower in the study group than in control (2.82 ± 2.4 ng/mL vs. 3.82 ± 2.8 ng/mL, P=0.005). When we analyzed the serum AMH levels according to age groups, the patients above 31 years showed significantly lower levels than control (31-35 years, 2.41±1.7 ng/mL vs. 3.84 ± 2.6 ng/mL, P=0.005; 36-40 years, 1.36 ± 2.0 ng/mL vs. 2.68 ± 2.7 ng/mL, P=0.018) The serum AMH levels didn't show any statistical difference in aspect of bilaterality, endometriosis stage, cyst size (≥6 cm).

Conclusion

We could consider relatively low serum AMH levels in patients with ovarian endometriosis after surgical treatment.

Keywords: Anti-Müllerian hormone, Ovarian endometriosis, Endometriosis, Ovarian reserve

Figures and Tables

Fig. 1
Serum anti-Müllerian hormone (AMH) concentration between study group and control group according to the age. Values are median (lines), 25-75th percentiles (boxes) and 95% confidence interval (whiskers). aP = 0.005, bP = 0.018.
kjog-55-935-g001
Table 1
Basal characteristics of study population
kjog-55-935-i001

Values are presented as mean ± standard deviation.

AMH, anti-Müllerian hormone; FSH, follicle stimulating hormone; LH, luteinizing hormone; TSH, thyroid stimulating hormone.

a,cP=0.005; b,fP=0.018; dP=0.044; eP=0.028.

Table 2
The postoperative serum AMH levels in patients with endometriosis according to the age group
kjog-55-935-i002

Values are presented as mean ± standard deviation.

AMH, anti-Müllerian hormone; NS, not significant.

References

1. Shebl O, Ebner T, Sommergruber M, Sir A, Tews G. Anti muellerian hormone serum levels in women with endometriosis: a case-control study. Gynecol Endocrinol. 2009. 25:713–716.
2. van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, et al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002. 17:3065–3071.
3. Deb S, Batcha M, Campbell BK, Jayaprakasan K, Clewes JS, Hopkisson JF, et al. The predictive value of the automated quantification of the number and size of small antral follicles in women undergoing ART. Hum Reprod. 2009. 24:2124–2132.
4. Domingues TS, Rocha AM, Serafini PC. Tests for ovarian reserve: reliability and utility. Curr Opin Obstet Gynecol. 2010. 22:271–276.
5. Steiner AZ. Clinical implications of ovarian reserve testing. Obstet Gynecol Surv. 2009. 64:120–128.
6. Riggs RM, Duran EH, Baker MW, Kimble TD, Hobeika E, Yin L, et al. Assessment of ovarian reserve with anti-Müllerian hormone: a comparison of the predictive value of anti-Müllerian hormone, follicle-stimulating hormone, inhibin B, and age. Am J Obstet Gynecol. 2008. 199:202.e1–202.e8.
7. Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009. 92:68–74.
8. Benaglia L, Somigliana E, Vercellini P, Abbiati A, Ragni G, Fedele L. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009. 24:2183–2186.
9. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002. 77:1148–1155.
10. Kim HO, Kang IS. Comparison of IVF outcomes in patients with endometriosis according to severity. Korean J Fertil Steril. 2006. 33:219–227.
11. Yang SH, Kim HO, Sung NY, Ahn HS, Choo YS, Yang KM, et al. In vitro fertilization outcomes in patients with advanced endometriosis after surgical treatment. Korean J Obstet Gynecol. 2011. 54:517–522.
12. Ahn YS, Kim JY, Cho YJ, Kim MJ, Kim HO, Park CW, et al. Correlation of basal AMH & ovarian response in IVF cycles; predictive value of AMH. Korean J Reprod Med. 2008. 35:309–317.
13. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007. 88:1568–1572.
14. Al-Fadhli R, Kelly SM, Tulandi T, Tanr SL. Effects of different stages of endometriosis on the outcome of in vitro fertilization. J Obstet Gynaecol Can. 2006. 28:888–891.
15. Muzii L, Bellati F, Palaia I, Plotti F, Manci N, Zullo MA, et al. Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part I: clinical results. Hum Reprod. 2005. 20:1981–1986.
16. Lemos NA, Arbo E, Scalco R, Weiler E, Rosa V, Cunha-Filho JS. Decreased anti-Müllerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. Fertil Steril. 2008. 89:1064–1068.
17. Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, et al. The post-operative decline in serum anti-Müllerian hormone correlates with the bilaterality and severity of endometriosis. Hum Reprod. 2011. 26:904–910.
18. Yoo JH, Kim HO, Cha SW, Park CW, Yang KM, Song IO, et al. Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation. Clin Exp Reprod Med. 2011. 38:93–97.
19. Visser J. Role of anti-Müllerian hormone in follicle recruitment and maturation. J Gynecol Obstet Biol Reprod (Paris). 2006. 35:2S30–22S4.
20. Chang HJ, Han SH, Lee JR, Jee BC, Lee BI, Suh CS, et al. Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-Müllerian hormone levels. Fertil Steril. 2010. 94:343–349.
21. La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC, et al. Anti-Müllerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2010. 16:113–130.
22. Campos CS, Vaamonde D, Andreoli C, Martins AC, Genro VK, Souza CA, et al. Follicular-fluid anti-Müllerian hormone concentration is similar in patients with endometriosis compared with non-endometriotic patients. Reprod Biomed Online. 2010. 21:470–473.
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