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Yoon, Park, Kuk, Oak, and Park: A case of ovarian dysgerminoma with gonadal dysgenesis in 29-year-old woman with 46,XX karyotype
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(10): 772-776.

Published online: 9 October 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.10.772

A case of ovarian dysgerminoma with gonadal dysgenesis in 29-year-old woman with 46,XX karyotype

So-yeon Yoon, MD1, Hyang Gi Park, MD1, Jin Yi Kuk, MD1, Soon Ae Oak, MD2, Jong Hoon Park, MD3

1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

2Department of Pathology, Ilsin Christian Hospital, Busan, Korea.

3Department of Obstetrics and Gynecology, Ilsin Christian Hospital, Busan, Korea.

Corresponding author: So-yeon Yoon, MD. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: +82-2-3410-3518, Fax: +82-2-3410-0630, soyeon.yoon@samsung.com

Received 30 April 2012       Revised 10 July 2012       Accepted 27 August 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gonadal dysgenesis occurs in rare case of ovarian tumor. Most tumors associated with gonadal dysgenesis were gonadoblastomas and dysgerminomas. In addition, premature ovarian insufficiency associated with these ovarian tumors in normal chromosomal type had not reported in many cases. A 29-year-old nulligravida woman who was concurrented with ovarian dysgerminoma and fibroma is presented. Measurements were made on serum lactate dehydrogenase, CA-125, CA 19-9 and pelvis ultrasonography and computed tomography. The clinical stage was IA and right salpingo-oophorectomy and wedge resection of the left ovary were done. On laboratory finding after operation on her serum follicular stimulating hormone was increased and E2 was decreased. The result of chromosomal analysis was 46,XX, normal. We represent here with brief review of literature one case of gonadal dysgenesis in nulligravida woman, associated with dysgerminoma, with normal karyotype.

Keywords: Dysgerminoma, Gonadal dysgenesis, Normal karyotype

Figures and Tables

Fig. 1
Right ovarian tumor finding: transvaginal ultrasound.
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Fig. 2
Abdomen-pelvis computed tomography.
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Fig. 3
Right ovarian tumor: operating finding.
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Fig. 4
Left ovarian nodules: operating finding.
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Fig. 5
Right ovarian dysgerminoma pathologic finding (H&E, ×400).
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