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Kim, Kim, Lee, Park, Park, and Jun: A case of juvenile xanthogranuloma involving skin and multiple systemic organs in a fetus
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(10): 756-760.

Published online: 9 October 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.10.756

A case of juvenile xanthogranuloma involving skin and multiple systemic organs in a fetus

Eunjin Kim, MD, Hye Young Kim, MD, Jae Ho Lee, MD, Chan-Wook Park, MD, PhD, Joong Shin Park, MD, PhD, Jong Kwan Jun, MD, PhD

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Corresponding author: Joong Shin Park, MD, PhD. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: +82-2-2072-3199, Fax: +82-2-762-3599, jsparkmd@snu.ac.kr

Received 30 May 2012       Revised 3 August 2012       Accepted 24 August 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Juvenile xanthogranuloma is a benign histiocytic proliferative disorder. It typically presents as a solitary, benign, rapidly growing cutaneous tumor that may regress spontaneously. Most of juvenile xanthogranuloma occur in infants and young children. We had experienced a case of juvenile xanthogranuloma in a fetus which involves multiple systemic organs. On prenatal ultrasonography, the fetus presented with pulmonary, perineal and hepatic nodules. The neonate was diagnosed with juvenile xanthogranuloma by the cutaneous and perineal nodule biopsy after birth. The neonate outpatient follow-up shows spontaneous regression without specific treatment. So we report a case with a brief review of the literature.

Keywords: Juvenile xanthogranuloma, Fetus, Systemic involvement, Multiple, Congenital

Figures and Tables

Fig. 1
Prenatal ultrasonographic findings, showing multiple neoplastic masses in lung (A, B), liver (C) and perineum (D).
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Fig. 2
Perineal mass, after birth.
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Fig. 3
Sonographic findings of liver masses, after birth (A, B), and after regression (C).
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