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Lee, Lee, Lee, Kim, and Lee: A Case of Recurrent Ovarian Granulosa Cell Tumor Associated with Sarcomatoid Change
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(7): 507-512.

Published online: 13 July 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.7.507

A Case of Recurrent Ovarian Granulosa Cell Tumor Associated with Sarcomatoid Change

Ju Ok Lee, MD1, Jung Ju Lee, MD1, Dae Hyung Lee, MD1, Mi Jin Kim, MD2, Doo Jin Lee, MD1

1Department of Obstetrics, Yeungnam University School of Medicine, Daegu, Korea.

2Department of Pathology, Yeungnam University School of Medicine, Daegu, Korea.

Corresponding author: Doo Jin Lee, MD. Department of Obstetrics and Gynecology, Yeungnam University School of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 705-717, Korea. Tel: +82-53-620-3435, Fax: +82-53-654-0676, djlee@med.yu.ac.kr

Received 16 March 2012       Revised 24 April 2012       Accepted 17 May 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Granulosa cell tumors of the ovary are malignancies that originate from the sex-cord stromal cells of the ovary and represent 2% to 5% of all ovarian cancers. Slow growth with a tendency for late recurrence characterizes a natural history of this tumor. So this tumor needs a prolonged follow-up. As a result of recent literature in Korea, the findings are 3 cases of juvenile granulosa cell tumor and 1 case of adult granulosa cell tumor. Previous case of adult granulosa cell tumor was presented recurrence with hepatic metastasis after 9 months of first diagnosis and operation. We describe here a 52-year-old women with recurrent granulosa cell tumor after total abdominal hysterectomy with right salpingo-oophorectomy and left ovarian wedge resection because of right ovarian granulosa cell tumor 12 years ago. Our case presented late recurrence character of granulosa cell tumor. We report 1 case of recurrent adult type granulosa cell tumor associated sarcomatoid change with a brief review of literatures.

Keywords: Granulosa cell tumor, Recurrent, Sarcomatoid change

Figures and Tables

Fig. 1
Pelvic computed tomography shows about 20 cm sized huge, lobulated, well-marginated cystic and solid mixed density mass lesion is seen in the pelvic cavity. (A) Non-enhance phase. (B) Delayed phase.
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Fig. 2
The sectioned surface of the tumor is solid, yellow to tan with focal cystic areas. Focal necrosis is also noted.
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Fig. 3
(A) Left ovary has normal appearance (H&E, ×10). (B) The tumor shows highly cellular diffuse growth pattern (H&E, ×100).
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Fig. 4
Mitotic figures are readily identified. The cells have occasional nuclear grooves (H&E, ×200).
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Fig. 5
Immunostains for alpha-inhibin and CD99 shows a diffuse, intensely positive reaction (Immunohistochemistry, ×200).
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Table 1
Profiles of patients with recurrent granulosa cell tumor of ovary
kjog-55-507-i001

TAH with BSO, total abdominal hysterectomy with both salpingo-oophorectomy; CAP, cyclophosphamide, doxorubicin, cisplatin; VAC, vincristine, actiomycin-D, cyclophosphamide; BEP, bleomycin, etoposide, cisplatin; CEC, cyclophosphamide, epirubicin, carboplatin; TC, paclitaxel, carboplatin.

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