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Lee, Moon, and Kim: Combined small cell carcinoma and adenocarcinoma arising in uterine cervix
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(4): 269-273.

Published online: 17 April 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.4.269

Combined small cell carcinoma and adenocarcinoma arising in uterine cervix

Hyunseung Lee, MD1, Youngjin Moon, MD2, Hyun Kim, MD3

1Department of Pathology, Yangji General Hospital, Seoul, Korea.

2Department of Gynecology, Cheju Halla General Hospital, Jeju, Korea.

3Department of Radiology, Cheju Halla General Hospital, Jeju, Korea.

Corresponding author: Hyunseung Lee, MD. Department of Pathology, Yangi General Hospital, 1636 Nambusunhwan-ro, Gwanak-gu, Seoul 151-852, Korea. Tel: +82-70-7410-9108, Fax: +82-2-879-1610, laghonda@naver.com

Received 5 January 2012       Revised 15 March 2012       Accepted 22 March 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report here on a case of combined small cell carcinoma and adenocarcinoma arising on uterine cervix. The patient was a 39-year-old woman who presented with uterine cervical mass. Colposcopic biopsy confirmed as adenocarcinoma and radical hysterectomy was performed. The mass, measuring in about 2 cm in greatest diameter, was mainly endophytic growing. Histopathologically, the mass was consisted of well differentiated adenocarcinoma from 2 to 9 o'clock directions of uterine cervix. From 9 to 11 o'clock directions, small cell carcinoma was detected. On results of special stain and immunohistochemistry, mucin stains and carcinoembryonic antigen were positive in area of adenocarcinoma. Chromogranin A and synaptophysin, stain for neuroendocrine markers, were positive in region of small cell carcinoma. This case indicates that the small cell carcinoma and adenocarcinoma can simultaneously occur in uterine cervix.

Keywords: Carcinoma, Small cell, Adenocarcinoma, Cervix Uteri

Figures and Tables

Fig. 1
Radiologic findings of the cervical tumor. (A) Pelvic magnetic resonance imaging shows the mass with increased signal intensity in the endocervical area of uterus. (B, C) Positron emission tomography (PET)/computerized tomography images show a hypermetabolic focus on lower uterine cervix. Note no evidence of distant tumor metastasis on PET scan.
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Fig. 2
(A) On microscopic findings, the mounted section shows that well differentiated adenocarcinoma of the cervix infiltrating the stroma. The inset shows pseudostratified nuclei and cribriform pattern (A; H&E, ×200). (B) Small cell carcinoma shows confluent sheets of darkly staining neoplastic cells infiltrate the stroma on mounted section. The inset shows the loose packed tumor cells with scant cytoplasm and small foci of necrosis (B; H&E, ×200).
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Fig. 3
Special stains and immunohistochemical stainings. (A) Adenocarcinoma (Periodic acid-schiff stain, ×400). (B) Carcinoembryonic antigen in adenocarcinoma (×400). (C) Chromogranin A in small cell carcinoma (×400). (D) Synaptophysin in small cell carcinoma (×400).
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