Abstract
Methods
We conducted a retrospective analysis of 57 premenopausal women who were suspected to have endometrial polyps and were examined by sonohysterography from October 2005 to July 2008. We evaluated changes in endometrial polyps by sonohysterography after observation for two or more menstrual cycles.
Results
The mean age of the patients was 37.7, and all patients were premenopausal. Forty-two patients had bleeding symptoms, the most common being intermenstrual spotting. Endometrial polyps regressed spontaneously in 15 out of 57 patients (26.3%). The endometrial polyp regression rate was not associated with symptoms, age, body mass index, gravida, parity, initial largest polyp diameter or interval between sonohysterography. Of the 42 patients with persistent polyps, 29 received surgical treatment. None of the patients had malignant lesions.
References
1. Peterson WF, Novak ER. Endometrial polyps. Obstet Gynecol. 1956. 8:40–49.
2. DeWaay DJ, Syrop CH, Nygaard IE, Davis WA, Van Voorhis BJ. Natural history of uterine polyps and leiomyomata. Obstet Gynecol. 2002. 100:3–7.
3. Lieng M, Istre O, Sandvik L, Qvigstad E. Prevalence, 1-year regression rate, and clinical significance of asymptomatic endometrial polyps: cross-sectional study. J Minim Invasive Gynecol. 2009. 16:465–471.
4. Widrich T, Bradley LD, Mitchinson AR, Collins RL. Comparison of saline infusion sonography with office hysteroscopy for the evaluation of the endometrium. Am J Obstet Gynecol. 1996. 174:1327–1334.
5. Goldstein SR, Monteagudo A, Popiolek D, Mayberry P, Timor-Tritsch I. Evaluation of endometrial polyps. Am J Obstet Gynecol. 2002. 186:669–674.
6. Caspi B, Appelman Z, Goldchmit R, Ashkenazi M, Haruvy Y, Hagay Z. The bright edge of the endometrial polyp. Ultrasound Obstet Gynecol. 2000. 15:327–330.
7. Cohen I, Azaria R, Aviram R, Bernheim J, Tepper R, Cordoba M, et al. Postmenopausal endometrial pathologies with tamoxifen treatment: comparison between hysteroscopic and hysterectomy findings. Gynecol Obstet Invest. 1999. 48:187–192.
8. Clevenger-Hoeft M, Syrop CH, Stovall DW, Van Voorhis BJ. Sonohysterography in premenopausal women with and without abnormal bleeding. Obstet Gynecol. 1999. 94:516–520.
9. Orvieto R, Bar-Hava I, Dicker D, Bar J, Ben-Rafael Z, Neri A. Endometrial polyps during menopause: characterization and significance. Acta Obstet Gynecol Scand. 1999. 78:883–886.
10. Ben-Arie A, Goldchmit C, Laviv Y, Levy R, Caspi B, Huszar M, et al. The malignant potential of endometrial polyps. Eur J Obstet Gynecol Reprod Biol. 2004. 115:206–210.
11. Reslová T, Tosner J, Resl M, Kugler R, Vávrová I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet. 1999. 262:133–139.
12. Preutthipan S, Herabutya Y. Hysteroscopic polypectomy in 240 premenopausal and postmenopausal women. Fertil Steril. 2005. 83:705–709.
13. Anastasiadis PG, Koutlaki NG, Skaphida PG, Galazios GC, Tsikouras PN, Liberis VA. Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol. 2000. 21:180–183.
14. Armenia CS. Sequential relationship between endometrial polyps and carcinoma of the endometrium. Obstet Gynecol. 1967. 30:524–529.
15. Gray LA, Robertson RW Jr, Christopherson WM. Atypical endometrial changes associated with carcinoma. Gynecol Oncol. 1974. 2:93–100.
16. Bakour SH, Khan KS, Gupta JK. The risk of premalignant and malignant pathology in endometrial polyps. Acta Obstet Gynecol Scand. 2000. 79:317–320.
17. Savelli L, De Iaco P, Santini D, Rosati F, Ghi T, Pignotti E, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol. 2003. 188:927–931.
18. Haimov-Kochman R, Deri-Hasid R, Hamani Y, Voss E. The natural course of endometrial polyps: could they vanish when left untreated? Fertil Steril. 2009. 92:828.e11-2.
19. Parsons AK, Lense JJ. Sonohysterography for endometrial abnormalities: preliminary results. J Clin Ultrasound. 1993. 21:87–95.
20. Bol S, Wanschura S, Thode B, Deichert U, Van de Ven WJ, Bartnitzke S, et al. An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12. Cancer Genet Cytogenet. 1996. 90:88–90.
21. Pal L, Niklaus AL, Kim M, Pollack S, Santoro N. Heterogeneity in endometrial expression of aromatase in polyp-bearing uteri. Hum Reprod. 2008. 23:80–84.
22. Maia H Jr, Pimentel K, Silva TM, Freitas LA, Zausner B, Athayde C, et al. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Gynecol Endocrinol. 2006. 22:219–224.
23. Tallini G, Vanni R, Manfioletti G, Kazmierczak B, Faa G, Pauwels P, et al. HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes. Lab Invest. 2000. 80:359–369.
24. Fletcher JA, Pinkus JL, Lage JM, Morton CC, Pinkus GS. Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chromosomes Cancer. 1992. 5:260–263.
25. Dal Cin P, Wanschura S, Kazmierczak B, Tallini G, Dei Tos A, Bullerdiek J, et al. Amplification and expression of the HMGIC gene in a benign endometrial polyp. Genes Chromosomes Cancer. 1998. 22:95–99.
26. Dal Cin P, Vanni R, Marras S, Moerman P, Kools P, Andria M, et al. Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res. 1995. 55:1565–1568.
27. Goldstein SR. Saline infusion sonohysterography. Clin Obstet Gynecol. 1996. 39:248–258.
28. Lindheim SR, Adsuar N, Kushner DM, Pritts EA, Olive DL. Sonohysterography: a valuable tool in evaluating the female pelvis. Obstet Gynecol Surv. 2003. 58:770–784.
29. Cho YJ, Kim ML, Kim JM, Joo KY, Lee IK. The rate of malignant endometrial polyps and it's associated factors. Korean J Obstet Gynecol. 2007. 50:180–186.
30. Goldstein SR. Use of ultrasonohysterography for triage of perimenopausal patients with unexplained uterine bleeding. Am J Obstet Gynecol. 1994. 170:565–570.
31. Wang JH, Zhao J, Lin J. Opportunities and risk factors for premalignant and malignant transformation of endometrial polyps: management strategies. J Minim Invasive Gynecol. 2010. 17:53–58.
32. Lee SC, Kaunitz AM, Sanchez-Ramos L, Rhatigan RM. The oncogenic potential of endometrial polyps: a systematic review and meta-analysis. Obstet Gynecol. 2010. 116:1197–1205.
33. Callen PW. Ultrasonography in obstetrics and gynecology. 2000. 4th ed. Philadelphia (PA): W.B. Saunders.
34. Wada-Hiraike O, Osuga Y, Hiroi H, Fujimoto A, Maruyama M, Yano T, et al. Sessile polyps and pedunculated polyps respond differently to oral contraceptives. Gynecol Endocrinol. 2011. 27:351–355.