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Chung, Park, Park, Kim, Chun, Cho, and Park: Association of genital Mycoplasmas infection in women who had preterm delivery and outcomes in premature infants
Original Article
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(3): 158-165.

Published online: 15 March 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.3.158

Association of genital Mycoplasmas infection in women who had preterm delivery and outcomes in premature infants

Hyun Kyung Chung, MD1, So Yun Park, MD1, Mi Hye Park, MD, PhD1, Yong Ju Kim, MD, PhD1, Sun Hee Chun, MD, PhD1, Su Jin Cho, MD, PhD2, Eun Ae Park, MD, PhD2

1Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea.

2Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Sun Hee Chun, MD, PhD. Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. Tel: +82-2-2650-2866, Fax: +82-2647-9860, shchun@ewha.ac.kr

Received 21 September 2011       Revised 5 December 2011       Accepted 19 December 2011

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

We conducted this study to evaluate the relationship between genital Mycoplasmas infection in women who had preterm delivery and the neontal outcomes.

Methods

We studied 116 women with preterm delivery (gestational age, ranged from 24 to 37 weeks) and their 116 premature infants born at Ewha Womans University Mokdong Hospital from August 2009 to December 2010. Culture for genital Mycoplasmas or a polymerase chain reaction was performed in vaginal fluid obtained from women who had preterm delivery. For perinatal outcomes, chorioamnionitis, funisitis and puerperal infection were analysed. We also evaluated the following neonatal data; birth weight, sex, small for gestational age, Apgar score, cord blood pH, ventilator care, hospital days, incidence of respiratory distress syndrome, bronchopulmonary dysplasia, sepsis, intraventricular hemorrhage and patent ductus arteriosus.

Results

Genital Mycoplasmas were isolated in 36.2% (42 of 116 patients). History of prior preterm birth was significantly higher and the cervical length at admission was significantly shorter in patients with genital Mycoplasmas infection (P < 0.05). Perinatal outcomes according to the Mycoplasmas infection and the neonatal outcomes were not statistically different between study and control groups. The relative risk of respiratory distress syndrome and bronchopulmonary dysplasia were 1.55 (95% confidence interval [CI], 0.65-3.70), and 1.24 (95% CI, 0.42-3.67), respectively.

Conclusion

There is higher incidence of prior preterm birth and shorter cervical length in patient with genital Mycoplasmas infection. However, genital Mycoplasmas infection does not affect the neonatal outcomes.

Keywords: Genital Mycoplasmas, Mycoplasma hominis, Ureaplasma urealyticum, Preterm birth, Premature infants

Figures and Tables

Table 1
Mycoplasma hominis and Ureaplasma urealyticum infection
kjog-55-158-i001

M, Mycoplasma hominis ; U, Ureaplasma urealyticum.

Table 2
Clinical characteristics
kjog-55-158-i002

Values are presented as mean ± standard deviation or number (%).

M, Mycoplasma hominis ; U, Ureaplasma urealyticum ; GDM, gestational diabetic mellitus; PROM, premature rupture of membrane.

aThis is the number except primiparity.

bP < 0.05

Table 3
Delivery outcomes according to Mycoplasma hominis and Ureaplasma urealyticum infection
kjog-55-158-i003

Values are presented as number (%).

Table 4
Effect of Mycoplasma hominis and Ureaplasma urealyticum infection on neonatal morbidity
kjog-55-158-i004

Values are presented as mean ± standard deviation or number (%).

CI, confidence interval; SGA, small for gestational age; RDS, respiratory distress syndrome; IVH, intraventricular hemorrhage; BPD, bronchopulmonary dysplasia; PDA, patent ductus arteriosus.

aNon-parametric analysis using Wilcoxon rank-sum test.

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