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Cheon, Lee, Kim, Choi, Park, and Hur: Two cases of primary malignant melanoma of vagina
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(12): 1020-1025.

Published online: 18 December 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.12.1020

Two cases of primary malignant melanoma of vagina

Juyoung Cheon, MD1, Soo Jeong Lee, MD1, Sul Ah Kim, MD1, Jeong In Choi, MD1, Sung Taek Park, MD2, Sooyoung Hur, MD, PhD1

1Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea.

2Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea.

Corresponding author: Sooyoung Hur, MD, PhD. Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel: +82-2-2258-6171, Fax: +82-2-595-1549, Hursy@catholic.ac.kr

Received 31 May 2012       Revised 27 August 2012       Accepted 9 October 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary malignant melanoma of the vagina is extremly rare disease. This disease is one of non-cutaneous melanomas and accounts for 0.3% of all malignant melanomas. The most common symptoms is vaginal bleeding because the disease is usually in advanced stage at first visit. An appropriate and effective treatment protocol has not been established. The prognosis is poorer than those of other vulvar melanomas. It has been known the tumor size is the most important prognostic factor determining the survival outcome. We reported two cases of primary malignant melanoma of the vagina with review of literature.

Keywords: Primary malignant melanoma, Vagina, Immunohistochemistry

Figures and Tables

Fig. 1
There is about 3.5×2.5×3.5 cm sized lobulated mass in the posterior wall of the vagina. (A) The mass shows intermediate signal intensity on T2-weighted transverse image. (B) T2-weighted sagital image shows that the mass is closely contact to anterior wall of the rectum with suspicious focal invasion.
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Fig. 2
A nodular protruding mass, measuring 3.4×2.8 cm, at the left vagina postoperative wall. It has a firm consistency.
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Fig. 3
(A) The malignant melanoma is composed of elongated tumor cells with prominent nucleoli (H&E, ×400). The mitosis is frequent (arrows). The immunohistochemical staining of S-100 protein (B) and HMB-45 antibody (C). The tumor cell were positive with both of them (original magnification, ×400).
kjog-55-1020-g003
Fig. 4
Gross appearance of vaginal mass, dark brown color pigmentated fungating mass in the lower third of vagina.
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Fig. 5
(A) The neoplastic cells involved subepithelial stromal tissue (H&E, ×100). (B) The malignant melanoma is composed of a epithelioid tumor cells with cytoplasmic brown melanin pigments and vesicular nuclei containing prominent nucleoli (H&E, ×400).
kjog-55-1020-g005

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