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Kim, Seo, Kim, Eom, Jeong, Byun, Kim, Lee, Sung, Kim, and Jeong: Small cell carcinoma, hypercalcemic type of the ovary
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(12): 1015-1019.

Published online: 18 December 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.12.1015

Small cell carcinoma, hypercalcemic type of the ovary

Su Seon Kim, MD1, Young Jin Seo, MD1, Mi Jung Kim, MD1, Hye Mi Eom, MD1, Eun Jeong Jeong, MD1, Jung Mi Byun, MD1, Young Nam Kim, MD1, 2, Kyoung Bok Lee, MD1, Moon Su Sung, MD1, Ki Tae Kim, MD1, 2, Dae Hoon Jeong, MD1, 2

1Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

2Department of Obstetrics and Gynecology, Institute for Clinical Research, Inje University, Busan, Korea.

Corresponding author: Dae Hoon Jeong, MD. Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan 614-735, Korea. Tel: +82-51-890-6374, Fax: +82-51-897-6380, obgynjeong@hanmail.net

Received 31 May 2012       Revised 1 August 2012       Accepted 4 September 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The patient was a 22-year-old woman, who presented with abdominal pain and palpable huge mass. The initial investigation by ultrasound examination showed a huge size heterogenous soild mass and then magnetic resonance imaging presented multilobulated, huge solid mass (16×13 cm) with heterogenous enhancement in left ovary. Serum calcium level was slightly elevated (10.6 mg/dL, normal less than 10.4 mg/dL) and cancer antigen 125 level was normal. She underwent a laparotomy and left salpingo-ophorectomy. Grossly, ovary consists of yellowish solid portion but not cystic portion and outer capsule was ruptured focally. The pathologic finding, including immunohistochemical finding, confirmed small cell carcinoma, hypercalcemic type from ovary. Now, She has been treated with adjuvant chemotherapy (cisplatin, adriamycin, etoposide, cyclophophamide). We report this case with brief review of literature.

Keywords: Ovarian cancer, Small cell carcinoma, Hypercalcemic type

Figures and Tables

Fig. 1
Magnetic resonance imaging (MRI). The coronal and sagittal T2-weighted MR images (A, B) show large multilobulated mass with heterogeneous high signal intensity and multifocal necrotic foci. The tumor is not invasion to adjacent organs, just displacement. Engorged tumor supply vascular structure is also detected in central portion (arrow in B).
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Fig. 2
Macroscopic findings. 18.0×13.0×8.0 cm, multilobulated, predominantly solid tumor.
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Fig. 3
Histological findings. (A) Mitoticaily active small-sized tumor cells are diffusely infiltrated (H&E, ×200). (B) Tumor cells show enlarged nuclei with scanty cytoplasm (H&E, ×400). (C) Immunohistochemical staining of the tumor showed positive for vimentin (×200).
kjog-55-1015-g003

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