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Cho, Kim, Chun, Cho, Park, and Park: Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies
Original Article
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2011; 54(9): 485-491.

Published online: 26 September 2011

DOI: https://doi.org/10.5468/KJOG.2011.54.9.485

Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies

Ah-Ra Cho, MD1, Young-Ju Kim, MD, PhD1, Sun-Hee Chun, MD, PhD1, Su-Jin Cho, MD, PhD2, Eun-Ae Park, MD, PhD2, Mi Hye Park, MD, PhD1

1Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea.

2Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Mi Hye Park, MD. Department of Obstetrics and Gynecology, Ewha Women's University Mokdong Hospital, Ewha Womans University School of Medicine, Mok 5-dong, Yangcheon-gu, Seoul 158-710, Korea. Tel: +82-2-2650-2631, Fax: +82-2-2647-9860, ewhapmh@ewha.ac.kr

Received 15 April 2011       Revised 30 May 2011       Accepted 8 June 2011

Copyright © 2011. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group.

Methods

This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay.

Results

Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05).

Conclusion

Sex dimorphism for adiponectin and the change of adiponectin in GDM offsprings, first appear in utero. Higher adiponectin levels in females or GDM offsprings reflect increased adiposity of the fetuses.

Keywords: Cord serum adiponectin, Gestational diabetes mellitus, Sex characteristics, Adiposity

Figures and Tables

Fig. 1
Correlation of gestational age to cord serum adiponectin in normal pregnancies.
kjog-54-485-g001
Fig. 2
Correlation of birth weight to cord serum adiponectin in normal pregnancies. Adjusted for gestational age, infant's sex.
kjog-54-485-g002
Fig. 3
Cord serum adiponectin concentration in normal pregnancies and gestational diabetes mellitus pregnancies. Adjusted for gestational age, infant's sex.
kjog-54-485-g001
Table 1
Clinical characteristics of mothers
kjog-54-485-i001

Values are presented as mean ± standard deviation (SD).

GDM, gestational diabetes mellitus; HbA1c, glycated hemoglobin.

Table 2
Clinical characteristics of newborns
kjog-54-485-i002

Values are presented as mean ± standard deviation (SD).

GDM, gestational diabetes mellitus.

Table 3
Sexual dimorphism in cord serum adiponectin
kjog-54-485-i003

Values are presented as mean ± standard deviation (SD).

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