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Lee, Yoon, Chung, and Park: The serum vitamin D nutritional status and its relationship with skeletal status in Korean postmenopausal women
Original Article
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2011; 54(5): 241-246.

Published online: 20 May 2011

DOI: https://doi.org/10.5468/KJOG.2011.54.5.241

The serum vitamin D nutritional status and its relationship with skeletal status in Korean postmenopausal women

Min Kyung Lee, MD1, Byung Koo Yoon, MD2, Ho Yeon Chung, MD3, Hyoung Moo Park, MD1

1Department of Obstetrics and Gynecology, Chung-Ang University College of Medicine, Seoul, Korea.

2Department of Obstetrics and Gynecology, Sungkyunkwan University College of Medicine, Seoul, Korea.

3Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, Korea.

Corresponding author: Hyoung Moo Park, MD. Department of Obstetrics and Gynecology, Chung-Ang University College of Medicine, 224-1 Heukseok-dong, Dongjak-gu, Seoul 156-755, Korea. Tel: +82-2-6299-3172, Fax: +82-2-6263-2187, hmpark@hananet.net

Received 14 March 2011       Revised 25 April 2011       Accepted 2 May 2011

Copyright © 2011. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

The purpose of this study was to evaluate the nutritional status of vitamin D and its relationship with skeletal status in postmenopausal Korean women.

Methods

We studied 322 ambulatory postmenopausal women recruited in Seoul, Korea. The research was performed from October 2008 to March 2009. Serum 25-hydroxyvitamin D (25[OH]D) concentration was measured by radioimmunoassay and serum parathyroid hormone (PTH) level was measured by immunoradiometric assay. The bone mineral densities were measured at the lumbar spine and femur using dual energy x-ray absorptiometry.

Results

The mean serum 25(OH)D level was 16.0 ± 7.1 ng/mL and the mean serum PTH level was 34.0 ± 13.7 pg/mL. About 90% of all studied postmenopausal women were in vitamin D inadequate status. Although serum vitamin D level was the lowest in osteoporotic postmenopausal women, no significant differences were found in serum level of vitamin D among normal, osteopenic, and osteoporotic women (P =0.4689). Vitamin D level in elderly women over 65 years was significant lower than non-elderly women (P =0.0011). But no significant differences were found in vitamin D levels between early and late postmenopausal women (P =0.9882). Serum vitamin D level in winter and spring was significantly lower than serum vitamin D level in autumn (P < 0.0001). Serum vitamin D level was negatively correlated with serum PTH level (r = -0.3054, P < 0.0001).

Conclusion

About three quarters of postmenopausal women were in vitamin D deficient status regardless of the status of bone health. Therefore, it is recommended to prescribe the supplemental vitamin D to improve bone health of postmenopausal Korean women.

Keywords: Menopause, Vitamin D, Bone health

Figures and Tables

Fig. 1
Vitamin D nutritional status according to bone health (P=0.4689).
kjog-54-241-g001
Fig. 2
Correlation between serum 25-hydroxyvitamin D (25OHD) and parathyroid hormone (PTH) (P<0.0001).
kjog-54-241-g002
Table 1
Clinical characteristics of total 322 postmenopausal subjects
kjog-54-241-i001

25(OH)D, 25-hydroxy vitamin D; PTH, parathyroid hormone; BMI, body mass index; SD, standard deviation.

Table 2
Vitamin D nutritional status
kjog-54-241-i002

25(OH)D, 25-hydroxy vitamin D.

Table 3
Vitamin D level and relationship with bone health
kjog-54-241-i003

SD, standard deviation; Min, minimum; Max, maximum.

P=0.0569.

Table 4
Vitamin D level according to age, menopause duration and seasonal variation
kjog-54-241-i004

SD, standard deviation; Min, minimum; Max, maximum.

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