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Kwak, Park, We, Choi, and Shin: A case report on successful pregnancy and delivery in a medulloblastoma patient
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2011; 54(3): 147-150.

Published online: 16 March 2011

DOI: https://doi.org/10.5468/KJOG.2011.54.3.147

A case report on successful pregnancy and delivery in a medulloblastoma patient

Se Hyoun Kwak, MD, In Yang Park, MD, Ji Sun We, MD, Mi Rang Choi, MD, Jong Chul Shin, MD

Department of Obstetrics and Gynecology, The Catholic University of Korea School of Medicine, Seoul, Korea.

Corresponding author: Jong Chul Shin, MD. Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. Tel: +82-2-2258-6169, Fax: +82-2-595-1549, jcshin@catholic.ac.kr

Received 15 December 2010       Revised 15 February 2011       Accepted 24 February 2011

Copyright © 2011. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Medulloblastomas are rare neoplasms in adults. Medulloblastomas are treated by surgical removal of the tumor followed by radiotherapy. Because craniospinal irradiation can damage the hypothalamic-pituitary axis, uterus, and ovaries, and consequently result in infertility, the probability of pregnancy is quite low. We managed a patient who had undergone resection of a posterior fossa medulloblastoma and received craniospinal irradiation, who conceived spontaneously during follow-up. She was diagnosed with a recurrent medulloblastoma with metastasis to the spine accompanied by headaches and back pain at 26 weeks gestation. Conservative treatment measures were utilized in an effort to prolong the pregnancy. She was delivered by cesarean section due to recurrent seizure activity at 29 weeks plus 3 days gestation. The neonate made favorable progress and was discharged in good condition.

Keywords: Medulloblastoma, Recurrence, Metastasis, Pregnancy

Figures and Tables

Fig. 1
T2 weighted coronal MR image of brain shows high signal at the bilateral cerebellum and vermis. These findings are old leukoencephalomalatic changes with atrophic changes. Dark signal dot (white arrow) at the left cerebellum is suggested hemangioma.
kjog-54-147-g001
Fig. 2
(A) Fat suppressed T2 weighted sagittal MR image of spin shows a small nodular mass (white arrow) with high signal on dorsal portion of spinal cord at C7 level. (B) Multiple lesions (white arrow heads) are also seen along intradural and extramedullary layer on the thoracolumbar spine level. These masses surround and compress spinal cord, and extend along the cauda equina.
kjog-54-147-g002

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