Journal List > Korean J Leg Med > v.39(2) > 1087964

Park, Jeong, and Lee: Homicidal Paraquat Poisoning in Exhumed Case

Abstract

Paraquat is a nonselective herbicide, but its lethal and toxic effects are well known. Although its chemical additives have an unpleasant taste, this can be shrouded in spicy foods or drinks with strong tastes, and some symptoms and signs of paraquat poisoning can be mistaken as natural disease. For this reason, it is not easy to consider the possibility of homicidal paraquat poisoning for a clinician or even for a forensic pathologist. We present a case of homicidal poisoning by paraquat with significant forensic findings from postmortem examination and with a review of relevant literature.

REFERENCES

1. Tsokos M. Forensic pathologic reviews. Vol. 4. Totowa: Humana Press Inc.;2006. p. 261–327.
2. Paraquat Information Center. Safety to humans [Internet]. Paraquat Information Center; [cited 2015 May 1]. Available from:. http://paraquat.com/safety/safety-to-humans.
3. So BH, Lee MJ, Kim H, et al. 2008 Database of Korean toxic exposures: a preliminary study. J Korean Soc Clin Toxicol. 2010; 8:51–60.
4. Kim YS, Lee H, Jung YK, et al. Paraquat poisoning by injection: 3 autopsy cases. Korean J Leg Med. 2000; 24:87–91.
5. Houze P, Baud FJ, Mouy R, et al. Toxicokinetics of paraquat in humans. Hum Exp Toxicol. 1990; 9:5–12.
crossref
6. Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology. 2002; 180:65–77.
crossref
7. Wilks MF, Tomenson JA, Fernando R, et al. Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka. Clin Toxicol (Phila). 2011; 49:21–8.
crossref
8. Kim JH, Gil HW, Yang JO, et al. Serum uric acid level as a marker for mortality and acute kidney injury in patients with acute paraquat intoxication. Nephrol Dial Transplant. 2011; 26:1846–52.
crossref
9. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011; 72:745–57.
crossref
10. Dinis-Oliveira RJ, de Pinho PG, Santos L, et al. Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications. PLoS One. 2009; 4:e7149.
crossref

Table 1.
Paraquat concentrations in postmortem tissues (ng/g of tissue), urine, and cardiac blood: comparison of our case with other cases
Tissue/Blood Concentration (ng/g or ng/mL)
Case 1 Case 2 Case 3 Case 4 Case 5 Our case
Lung 11,856 660 5,095 2,231 0,500 0.8
Liver 04,355 340 0,973 0,879 0,100 1.3
Spleen Not done Not done Not done Not done Not done 5.5
Kidney 05,662 575 1,044 1,145 0,998 4.2
Heart 000,23 001 000,3 000,7 Not detected Not done
Duodenal wall 03,100 260 2,320 0,168 2,830 Not done
Gastric wall 01,234 190 0,200 00,94 0,160 1.5
Diaphragm 00,305 016 0,130 0,131 0,010 Not done
Urine 13,539 078 0,592 0,177 0,500 Not done
Cardiac blood 19,500 Not detected 0,290 00,90 Not detected Not detected
Bone Not done Not done Not done Not done Not done 2.3

Adopted from Dinis-Oliveira RJ, et al. PLoS One 2009;4:e7149, according to the Creative Commons License of PLoS [10].

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