Journal List > J Korean Soc Radiol > v.67(6) > 1087199

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Seo, Kim, Park, Lee, Ryu, and Jung: Apocrine Ductal Carcinoma In Situ of the Breast Presented Mass with Morphological Change on Follow-Up Ultrasound: A Report of Case
Breast Radiology
Journal of the Korean Society of Radiology

Journal of the Korean Society of Radiology 2012; 67(6): 461-464.

Published online: 18 December 2012

DOI: https://doi.org/10.0000/jksr.2012.67.6.461

Apocrine Ductal Carcinoma In Situ of the Breast Presented Mass with Morphological Change on Follow-Up Ultrasound: A Report of Case

Gi Young Seo, MD1, Soo Jin Kim, MD1, Sung Hee Park, MD1, Sun Jin Lee, MD1, Han Suk Ryu, MD2, Yoon Yang Jung, MD2

1Department of Radiology, Chung-Ang University Hospital, Seoul, Korea.

2Department of Pathology, Chung-Ang University Hospital, Seoul, Korea.

Corresponding author: Soo Jin Kim, MD. Department of Radiology, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, Korea. Tel. 82-2-6299-3218, Fax. 82-2-6299-3231, ksj1567@hanmail.net

Received 14 August 2012       Accepted 5 October 2012

Copyright © 2012 The Korean Society of Radiology

Abstract

Apocrine carcinoma in situ of breast is a rare, unique, and morphologically distinct type of breast carcinoma. Low-grade apocrine ductal carcinoma in situ (DCIS) and apocrine metaplasia with atypia are the pathologic spectrum of apocrine breast lesions. Differentiating these two lesions is difficult due to partial microscopic overlap. We describe a case of apocrine DCIS which presented an asymptomatic hypoechoic mass with morphological change on a follow up ultrasonography.

Keywords: Apocrine Ductal Carcinoma, Ductal Carcinoma In Situ, Apocrine Metaplasia, Breast Carcinoma, Ultrasound Breast

Figures and Tables

Fig. 1
A 60-year-old asymptomatic woman.
A. Initial breast ultrasonography revealed a 0.7 × 0.3 × 0.3 cm sized well-circumscribed hypoechoic mass in the left breast in the direction of 3-o'clock approximately 1 cm from the nipple.
B, C. Follow up ultrasonography after 1.5 year shows morphologic change with a newly developed indistinct margin, irregular shape and mild echogenic halo (B: longitudinal image, C: transverse image).
D. Photomicrograph shows apocrine ductal carcinoma in situ characterized by abundant eosinophilic cytoplasm and moderate nuclear pleomorphism (Hematoxylin and Eosin, × 100).
E. Photomicrograph of specimen shows a myoepithelial layer around the well-defined island of malignant cells. The neoplastic cells are negative (high molecular weight cytokeratin, × 200).
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