Journal List > J Korean Soc Radiol > v.66(1) > 1087135

Jeon, Jin, Choi, Han, Le, and Chung: Micro CT Findings on Microcalcification Using a Paraffin Block of Breast Specimens: A Preliminary Study

Abstract

Purpose

We compared micro CT images with mammography images to evaluate microcalcifications in breast specimens in paraffin blocks.

Materials and Methods

We enrolled 30 patients who had a biopsy of a breast mass that included microcalcifications. We did mammography and micro CT for paraffin blocks of that breast specimen. We evaluated numbers (0, absence; 1, less than 5; 2, 5-10; 3, more than 10) and sizes of microcalcifications. We used the Mann-Whitney test to statistically evaluate differences in the number of microcalcifications between the two imaging methods. We also measured the longest size of the microcalcifications using measurement in PACS.

Results

The proportions of microcalcifications in specimens in paraffin blocks on mammography and micro CT were 10/30 (30%) and 11/30 (36.6%), respectively. The scores for microcalcifications on micro CT and mammography were 0.8 ± 1.2 and 0.73 ± 1.2, respectively (p = 0.8001). The sizes of microcalcifications ranged from 0.1-0.5 mm (mean, 0.25 ± 0.17 mm) on micro CT.

Conclusion

Micro CT may be a new and promising technique to verify the evaluation by mammography of microcalcifications in breast tissue.

References

1. Ritman EL. Micro-computed tomography-current status and developments. Annu Rev Biomed Eng. 2004. 6:185–208.
2. Lee JA, Jin GY, Bok SM, Han YM, Park SJ, Lee YC, et al. Utility of micro CT in a murine model of bleomycin-induced lung fibrosis. Tuberc Respir Dis. 2009. 67:436–444.
3. Milan JL, Planell JA, Lacroix D. Simulation of bone tissue formation within a porous scaffold under dynamic compression. Biomech Model Mechanobiol. 2010. 9:583–596.
4. Feldkamp JM, Schroer CG, Patommel J, Lengeler B, Günzler TF, Schweitzer M, et al. Compact x-ray microtomography system for element mapping and absorption imaging. Rev Sci Instrum. 2007. 78:073702.
5. Ajiro Y, Tokuhashi Y, Matsuzaki H, Nakajima S, Ogawa T. Impact of passive smoking on the bones of rats. Orthopedics. 2010. 33:90–95.
6. Kramer R, Khoury HJ, Vieira JW, Robson Brown KA. Skeletal dosimetry for external exposures to photons based on microCT images of spongiosa: consideration of voxel resolution, cluster size, and medullary bone surfaces. Med Phys. 2009. 36:5007–5016.
7. Fatemi-Ardekani A, Boylan C, Noseworthy MD. Identification of breast calcification using magnetic resonance imaging. Med Phys. 2009. 36:5429–5436.
8. Liu F, Misra P, Lunsford EP, Vannah JT, Liu Y, Lenkinski RE, et al. A dose- and time-controllable syngeneic animal model of breast cancer microcalcification. Breast Cancer Res Treat. 2010. 122:87–94.
9. Jackman RJ, Rodriguez-Soto J. Breast microcalcifications: retrieval failure at prone stereotactic core and vacuum breast biopsy--frequency, causes, and outcome. Radiology. 2006. 239:61–70.
10. Liberman L, Drotman M, Morris EA, LaTrenta LR, Abramson AF, Zakowski MF, et al. Imaging-histologic discordance at percutaneous breast biopsy. Cancer. 2000. 89:2538–2546.
11. Kumaraswamy V, Carder PJ. Examination of breast needle core biopsy specimens performed for screen-detected microcalcification. J Clin Pathol. 2007. 60:681–684.
12. Lagios MD, Parker SH. Microcalcification in a core or needle localized biopsy in which it is the radiologic target are a "totally inconsequential and inappropriate function" for a pathologist. Am J Surg Pathol. 2002. 26:1238–1239. author reply 1239-1240.
13. Lai CJ, Shaw CC, Chen L, Altunbas MC, Liu X, Han T, et al. Visibility of microcalcification in cone beam breast CT: effects of X-ray tube voltage and radiation dose. Med Phys. 2007. 34:2995–3004.
14. Vengrenyuk Y, Cardoso L, Weinbaum S. Micro-CT based analysis of a new paradigm for vulnerable plaque rupture: cellular microcalcifications in fibrous caps. Mol Cell Biomech. 2008. 5:37–47.
15. Rollano-Hijarrubia E, Manniesing R, Niessen WJ. Selective deblurring for improved calcification visualization and quantification in carotid CT angiography: validation using micro-CT. IEEE Trans Med Imaging. 2009. 28:446–453.
16. Jin H, Ham K, Chan JY, Butler LG, Kurtz RL, Thiam S, et al. High resolution three-dimensional visualization and characterization of coronary atherosclerosis in vitro by synchrotron radiation X-ray microtomography and highly localized X-ray diffraction. Phys Med Biol. 2002. 47:4345–4356.
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