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Jeon, Jin, Choi, Han, Le, and Chung: Micro CT Findings on Microcalcification Using a Paraffin Block of Breast Specimens: A Preliminary Study
Breast Radiology
Journal of the Korean Society of Radiology

Journal of the Korean Society of Radiology 2012; 66(1): 63-68.

Published online: 12 January 2012

DOI: https://doi.org/10.0000/jksr.2012.66.1.63

Micro CT Findings on Microcalcification Using a Paraffin Block of Breast Specimens: A Preliminary Study

Su-Bin Jeon, MD1, Gong-Yong Jin, MD1, Eun-Jeong Choi, MD1, Young-Min Han, MD1, Jae-A Le, MD1, Myung Ja Chung, MD2

1Department of Radiology, Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

2Department of Pathology, Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

Corresponding author: Gong-Yong Jin, MD. Department of Radiology, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 561-712, Korea. Tel. 82-63-250-2307, Fax. 82-63-272-0481, gyjin@chonbuk.ac.kr

Received 15 July 2011       Accepted 20 October 2011

Copyright © 2012 The Korean Society of Radiology

Abstract

Purpose

We compared micro CT images with mammography images to evaluate microcalcifications in breast specimens in paraffin blocks.

Materials and Methods

We enrolled 30 patients who had a biopsy of a breast mass that included microcalcifications. We did mammography and micro CT for paraffin blocks of that breast specimen. We evaluated numbers (0, absence; 1, less than 5; 2, 5-10; 3, more than 10) and sizes of microcalcifications. We used the Mann-Whitney test to statistically evaluate differences in the number of microcalcifications between the two imaging methods. We also measured the longest size of the microcalcifications using measurement in PACS.

Results

The proportions of microcalcifications in specimens in paraffin blocks on mammography and micro CT were 10/30 (30%) and 11/30 (36.6%), respectively. The scores for microcalcifications on micro CT and mammography were 0.8 ± 1.2 and 0.73 ± 1.2, respectively (p = 0.8001). The sizes of microcalcifications ranged from 0.1-0.5 mm (mean, 0.25 ± 0.17 mm) on micro CT.

Conclusion

Micro CT may be a new and promising technique to verify the evaluation by mammography of microcalcifications in breast tissue.

Keywords: X-Ray Microtomography, Microcalcification, Breast

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