Journal List > J Korean Soc Radiol > v.66(3) > 1087089

TOOLS
Nam, Lee, Kim, Kim, Kang, and Lee: Serial CT Findings of Resolving Extramedullary Hematopoiesis as Unilateral Posterior Mediastinal Mass after Splenectomy in Hereditary Spherocytosis: A Case Report
Chest Radiology

Journal of the Korean Society of Radiology 2012; 66(3): 263-266.

Published online: 31 March 2012

DOI: https://doi.org/10.3348/jksr.2012.66.3.263

Serial CT Findings of Resolving Extramedullary Hematopoiesis as Unilateral Posterior Mediastinal Mass after Splenectomy in Hereditary Spherocytosis: A Case Report

Mi Yeon Nam, MD, Ju Won Lee, MD, Yeo Ju Kim, MD, Youn Jeong Kim, MD, Young Hye Kang, MD, Kyung Hee Lee, MD

Department of Radiology, Inha University Hospital, Incheon, Korea.

Corresponding author: Kyung Hee Lee, MD. Department of Radiology, Inha University Hospital, 7-206 Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, Korea. Tel. 82-32-890-2769, Fax. 82-32-890-2743, khlmay@hanmail.net

Received 11 October 2011       Accepted 11 December 2011

Copyright © 2012 The Korean Society of Radiology

Abstract

Intrathoracic extramedullary hematopoiesis (EMH) is a rare condition of the hereditary spherocytosis. EMH usually regresses or disappears after treatment; such as splenectomy in the case of spherocytosis. We report a case of hereditary spherocytosis. It is presented with an unilateral paravertebral posterior mediastinal mass. After splenectomy, it revealed shrinkage and fatty replacement on serial CT scans.

Keywords: Extramedullary Hematopoiesis, Posterior Mediastinal Mass, Hereditary Spherocytosis

Figures and Tables

Fig. 1

A 46-year-old man with hereditary spherocytosis.

A. Contrast-enhanced CT scan of the lower thorax shows well demarcated homogenous soft tissue lesion in left paravertebral area at the level of T11.
B. CT image obtained 6 months after splenectomy reveals newly appeared low attenuated portion (arrow) in the paravertebral mass without change in size.
C. CT image obtained 18 months after splenectomy shows shrinkage of the left paravertebral mass with near total fat replacement.
jksr-66-263-g001

References

1. Gogia P, Goel R, Nayar S. Extramedullary paraspinal hematopoiesis in hereditary spherocytosis. Ann Thorac Med. 2008; 3:64–66.
2. Berkmen YM, Zalta BA. Case 126: extramedullary hematopoiesis. Radiology. 2007; 245:905–908.
3. Abe T, Yachi A, Ishii Y, Igarashi T, Tanaka H, Yoshida Y, et al. Thoracic extramedullary hematopoiesis associated with hereditary spherocytosis. Intern Med. 1992; 31:1151–1154.
4. Kwak HS, Lee JM. CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis. J Korean Med Sci. 2000; 15:460–462.
5. Granjo E, Bauerle R, Sampaio R, Manata P, Torres N, Quintanilha A. Extramedullary hematopoiesis in hereditary spherocytosis deficient in ankyrin: a case report. Int J Hematol. 2002; 76:153–156.
6. Lawson JP, Ablow RC, Pearson HA. The ribs in thalassemia. II. The pathogenesis of the changes. Radiology. 1981; 140:673–679.
7. Marchiori E, Escuissato DL, Irion KL, Zanetti G, Rodrigues RS, Meirelles GS, et al. Extramedullary hematopoiesis: findings on computed tomography scans of the chest in 6 patients. J Bras Pneumol. 2008; 34:812–816.
8. Xiros N, Economopoulos T, Papageorgiou E, Mantzios G, Raptis S. Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with hereditary spherocytosis. Ann Hematol. 2001; 80:38–40.
9. Ozdemir A, Güngör F, Tunçdemir F, Cubuk M, Karayalçin B. Scintigraphic diagnosis of intrathoracic extramedullary hematopoiesis in a patient with beta-thalassemia. Ann Nucl Med. 1998; 12:149–151.
10. Chourmouzi D, Pistevou-Gompaki K, Plataniotis G, Skaragas G, Papadopoulos L, Drevelegas A. MRI findings of extramedullary haemopoiesis. Eur Radiol. 2001; 11:1803–1806.
TOOLS
Similar articles