The pentalogy of Cantrell is a rare thoraco-abdominal disruption with a variable combination of defects involving the abdominal wall, diaphragm, pericardium, sternum, and heart. Herein, we report the multi-detector computed tomography (MDCT) findings of Cantrell's pentalogy in a neonate. A MDCT proved to be useful and complementary for the diagnosis of Cantrell's pentalogy and evaluation of its associated anomalies.