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Choi, Seo, Kim, and Yoon: The Corpus Callosum Area and Brain Volume in Alzheimer's Disease, Mild Cognitive Impairment and Healthy Controls
Original Article

Journal of the Korean Society of Radiology 2009; 61(1): 1-8.

Published online: 31 July 2009

DOI: https://doi.org/10.3348/jksr.2009.61.1.1

The Corpus Callosum Area and Brain Volume in Alzheimer's Disease, Mild Cognitive Impairment and Healthy Controls

Hee Seok Choi, M.D.1, 2, Hyung Suk Seo, M.D.3, Kwang Ki Kim, M.D.4, Yup Yoon, M.D.1

Department of Radiology, Dongguk University International Hospital, Goyang-si, Gyeonggi-do, Korea.

2Department of Radiology, Seoul National University Bundang Hospital, Seong Nam-si, Gyeongido, Korea.

3Department of Radiology, Korea University Ansan Hospital, Ansan-si, Gyunggi-do, Korea.

4Department of Neurology, Dongguk University International Hospital, Goyang-si, Gyeonggi-do, Korea.

Address reprint requests to : Hyung Suk Seo, M.D., Department of Radiology, Korea University Ansan Hospital, 516 Gojan-dong, Danwon-gu, Ansan-si, Gyunggi-do, 425-707, Korea. Tel. 82-31-412-5247, Fax. 82-31-961-8281, casebase@hanmail.net

Copyright © 2009 The Korean Society of Radiology

Abstract

Purpose

To compare the corpus callosum (CC) area and brain volume among individuals with Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy controls (HC).

Materials and Methods

To evaluate the relationship of CC area and brain volume in 111 subjects (M:F = 48:63; mean age, 56.9 years) without memory disturbance and 28 subjects (11:17; 66.7years) with memory disturbance. The 11 AD (3:8; 75.7 years), 17 MCI (8:9; 60.9 years) and 28 selected HC (11:17; 66.4 years) patients were investigated for comparison of their CC area and brain volume.

Results

A good positive linear correlation was found between CC area and brain volume in subjects without and with memory disturbance (r = 0.64 and 0.66, respectively, p < 0.01). The CC area and brain volume in AD patients (498.7 ± 72 mm2, 715.4 ± 107 cm3) were significantly smaller than in MCI patients (595.9 ± 108, 844.1 ± 85) and the HCs (563.2 ± 75, 818.9 ± 109) (p < 0.05). The CC area and brain volume were not significantly different between MCI patients and the HCs.

Conclusion

The CC area was significantly correlated with brain volume. Both CC area and brain volume were significantly smaller in the AD patients

Keywords: Alzheimer's disease, Cognition disorders, Corpus callosum, Magnetic resonance (MR), Brain

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