Journal List > Endocrinol Metab > v.27(1) > 1085991

Kim, Choi, and Park: A Case of Sunitinib-Induced Destructive Thyroiditis

Abstract

Sunitinib is a multi-targeted tyrosine-kinase inhibitor used for gastrointestinal stromal tumors and renal cell carcinoma (RCC). Several recent studies have reported sunitinib-induced hypothyroidism and thyroid dysfunction; however, the underlying mechanisms are not clear. Here, we report a patient with metastatic RCC, who developed destructive thyroidtis due to sunitinib treatment. The course followed in this case may be useful in understanding the clinical course of sunitinib-induced thyroiditis.

Figures and Tables

Fig. 1
The ultrasonogram shows slightly decreased thyroid volume with normal vascularity at hospital day 2.
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Fig. 2
A radionuclide thyroid scan with 99mtechnetium demonstrate decreased ratioactivity in the anterior neck at hospital day 5.
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Fig. 3
Thyroid stimulating hormone (TSH) level was changed according to the sunitinib treatment cycle. 1st-6th, cycle number of sinitinib treatment. D, day.
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Table 1
The changes in thyroid function tests according to sunitinib treatment cycle
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Normal values: T3, 65-150 ng/dL; Free T4, 0.78-1.54 ng/dL; TSH, 0.35-5.5 µlU/mL. TSH, thyroid stimulating hormone.

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