Journal List > Endocrinol Metab > v.27(1) > 1085978

Kim, Park, Yu, Kang, Ryu, Lee, Hong, Kim, Yoo, Ihm, Choi, and Yoo: Impact of Serum Adiponectin Concentration on Progression of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Abstract

Background

Increased cardiovascular events, which is the leading cause of death in type 2 diabetic patients, are mainly caused by accelerated atherosclerosis. Adiponectin has been suggested as a risk factor for cardiovascular diseases in cross-sectional studies. However, little is known about the impact of adiponectin on the progression of carotid atherosclerosis in type 2 diabetic patients. This study was conducted to evaluate the impact of early adiponectin levels on the progression of carotid atherosclerosis.

Methods

From March 2009, 150 patients with type 2 diabetes were consecutively enrolled in our affiliated outpatient clinic. Anthropometric and biochemical data, including adiponectin levels, were measured in each participant. We measured the carotid intima-media thickness (CIMT) at baseline and at 1-year follow-up (n = 111). Then, we prospectively studied the relationship between the serum adiponectin levels and the progression of CIMT for 1 year.

Results

Adiponectin levels negatively correlated with CIMT (r = -0.219, P = 0.015). Moreover, mean progression of CIMT was 0.016 ± 0.040 mm. However, there was no correlation between adiponectin levels and the progression of CIMT within 1-year follow-up period (r = -0.156, P = 0.080). Age (β = 0.556, P = 0.004), LDL cholesterol (β = 0.276, P = 0.042), and A1C (β = 0.309, P = 0.038) were found to be independent risk factors for CIMT. However, A1C (β = 0.311, P = 0.042) was found to be the only independent risk factor for the progression of CIMT.

Conclusion

In our study, adiponectin levels were negatively associated with CIMT. However, it did not affect the progression of CIMT at 1-year follow-up. Overall glycemic control is the most important factor in the progression of CIMT in patients with type 2 diabetes.

Figures and Tables

Fig. 1
Correlation between serum adiponectin concentration (log transformed) and baseline carotid artery intima-media thickness (CIMT). (r = -0.219, P = 0.015).
enm-27-31-g001
Fig. 2
Correlation between serum adiponectin concentration (log transformed) and progression of carotid artery intima-media thickness (CIMT) (r = -0.156, P = 0.080).
enm-27-31-g002
Table 1
Clinical and biochemical characteristics of the subjects according to progression of carotid intima-media thickness
enm-27-31-i001

Values are expressed as mean ± SD.

CIMT, carotid intima-media thickness; DPP4, dipeptidyl peptidase-4; HDL, high density lipoprotein; HOMA-IR, homeostatic model assessment for insulin resistance; LDL, low-density lipoprotein; Ln, lymph node; RAS, renin angiotensin system.

Table 2
Differences in medication use in 1 year
enm-27-31-i002

Values are expressed as %.

DPP4, dipeptidyl peptidase- 4; RAS, renin angiotensin system.

Table 3
Multivariate logistic regression modeling for predictors of carotid artery intima-media thickness in type 2 diabetic patients
enm-27-31-i003

BMI, body mass index; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; LDL-C, low density lipoprotein cholesterol; Ln, lymph node.

Table 4
Multivariate logistic regression modeling for predictors of progression of carotid artery intima-media thickness in type 2 diabetic patients
enm-27-31-i004

BMI, body mass index; CIMT, carotid artery intima-media thickness; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; LDL-C, low density lipoprotein cholesterol; Ln, lymph node.

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